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首页> 美国卫生研究院文献>Biomedical Optics Express >Detecting tissue optical and mechanical properties with an ultrasound modulated optical imaging system in reflection detection geometry
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Detecting tissue optical and mechanical properties with an ultrasound modulated optical imaging system in reflection detection geometry

机译：使用超声调制光学成像系统以反射检测几何形状检测组织的光学和机械性能

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摘要

Tissue optical and mechanical properties are correlated to tissue pathologic changes. This manuscript describes a dual-mode ultrasound modulated optical imaging system capable of sensing local optical and mechanical properties in reflection geometry. The optical characterisation was achieved by the acoustic radiation force assisted ultrasound modulated optical tomography (ARF-UOT) with laser speckle contrast detection. Shear waves generated by the ARF were also tracked optically by the same system and the shear wave speed was used for the elasticity measurement. Tissue mimicking phantoms with multiple inclusions buried at 11 mm depth were experimentally scanned with the dual-mode system. The inclusions, with higher optical absorption and/or higher stiffness than background, were identified based on the dual results and their stiffnesses were quantified. The system characterises both optical and mechanical properties of the inclusions compared with the ARF-UOT or the elasticity measurement alone. Moreover, by detecting the backward scattered light in reflection detection geometry, the system is more suitable for clinical applications compared with transmission geometry.
机译：组织的光学和机械性质与组织病理变化相关。该手稿描述了一种双模超声调制光学成像系统，该系统能够感应反射几何形状中的局部光学和机械特性。光学表征是通过声辐射力辅助超声调制光学层析成像（ARF-UOT）和激光斑点对比检测来实现的。 ARF产生的剪切波也可以通过相同的系统进行光学跟踪，并且将剪切波速度用于弹性测量。用双模系统实验性地扫描了具有11mm深度掩埋的多个内含物的模仿组织的模型。根据对偶结果鉴定了具有比背景更高的光吸收和/或更高的刚度的夹杂物，并对它们的刚度进行了定量。与ARF-UOT或单独进行弹性测量相比，该系统可表征夹杂物的光学和机械性能。此外，通过检测反射检测几何形状中的向后散射光，与透射几何形状相比，该系统更适合于临床应用。

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