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首页> 美国卫生研究院文献>Biomedical Optics Express >In vivo demonstration of reflection artifact reduction in photoacoustic imaging using synthetic aperture photoacoustic-guided focused ultrasound (PAFUSion)
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In vivo demonstration of reflection artifact reduction in photoacoustic imaging using synthetic aperture photoacoustic-guided focused ultrasound (PAFUSion)

机译：使用合成孔径光声引导聚焦超声（PAFUSion）进行光声成像中反射伪影减少的体内演示

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Reflection artifacts caused by acoustic inhomogeneities are a critical problem in epi-mode biomedical photoacoustic imaging. High light fluence beneath the probe results in photoacoustic transients, which propagate into the tissue and reflect back from echogenic structures. These reflection artifacts cause problems in image interpretation and significantly impact the contrast and imaging depth. We recently proposed a method called PAFUSion (Photoacoustic-guided focused ultrasound) to identify such reflection artifacts in photoacoustic imaging. In its initial version, PAFUSion mimics the inward-travelling wavefield from small blood vessel-like PA sources by applying ultrasound pulses focused towards these sources, and thus provides a way to identify the resulting reflection artifacts. In this work, we demonstrate reduction of reflection artifacts in phantoms and in vivo measurements on human volunteers. In view of the spatially distributed PA sources that are found in clinical applications, we implemented an improved version of PAFUSion where photoacoustic signals are backpropagated to imitate the inward travelling wavefield and thus the reflection artifacts. The backpropagation is performed in a synthetic way based on the pulse-echo acquisitions after transmission on each single element of the transducer array. The results provide a direct confirmation that reflection artifacts are prominent in clinical epi-photoacoustic imaging, and that PAFUSion can strongly reduce these artifacts to improve deep-tissue photoacoustic imaging.
机译：由声学不均匀性引起的反射伪像是Epi模式生物医学光声成像中的关键问题。探头下方的高光通量导致光声瞬变，该瞬变传播到组织中并从回声结构反射回去。这些反射伪像会导致图像解释出现问题，并严重影响对比度和成像深度。我们最近提出了一种称为PAFUSion（光声引导聚焦超声）的方法，以识别光声成像中的此类反射伪像。在其初始版本中，PAFUSion通过施加聚焦于小血管状PA源的超声脉冲来模拟这些血管源的向内行波场，从而提供了一种识别产生的反射伪像的方法。在这项工作中，我们证明了减少幻影的反射伪影以及对人类志愿者的体内测量。考虑到在临床应用中发现的空间分布的PA源，我们实现了PAFUSion的改进版本，在该版本中，光声信号被反向传播以模仿向内传播的波场，从而模仿反射伪像。反向传播是基于在换能器阵列的每个单个元件上传输之后的脉冲回波采集以合成方式执行的。该结果直接证实了反射伪影在临床落射光声成像中很突出，并且PAFUSion可以大大减少这些伪影，从而改善深部组织的光声成像。

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