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首页> 美国卫生研究院文献>Biomedical Optics Express >Analysis of the potential for non-invasive imaging of oxygenation at heart depth using ultrasound optical tomography (UOT) or photo-acoustic tomography (PAT)
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Analysis of the potential for non-invasive imaging of oxygenation at heart depth using ultrasound optical tomography (UOT) or photo-acoustic tomography (PAT)

机译：使用超声光学层析成像（UOT）或光声层析成像（PAT）分析无创性心脏深度氧合成像的潜力

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Despite the important medical implications, it is currently an open task to find optical non-invasive techniques that can image deep organs in humans. Addressing this, photo-acoustic tomography (PAT) has received a great deal of attention in the past decade, owing to favorable properties like high contrast and high spatial resolution. However, even with optimal components PAT cannot penetrate beyond a few centimeters, which still presents an important limitation of the technique. Here, we calculate the absorption contrast levels for PAT and for ultrasound optical tomography (UOT) and compare them to their relevant noise sources as a function of imaging depth. The results indicate that a new development in optical filters, based on rare-earth-ion crystals, can push the UOT technique significantly ahead of PAT. Such filters allow the contrast-to-noise ratio for UOT to be up to three orders of magnitude better than for PAT at depths of a few cm into the tissue. It also translates into a significant increase of the image depth of UOT compared to PAT, enabling deep organs to be imaged in humans in real time. Furthermore, such spectral holeburning filters are not sensitive to speckle decorrelation from the tissue and can operate at nearly any angle of incident light, allowing good light collection. We theoretically demonstrate the improved performance in the medically important case of non-invasive optical imaging of the oxygenation level of the frontal part of the human myocardial tissue. Our results indicate that further studies on UOT are of interest and that the technique may have large impact on future directions of biomedical optics.
机译：尽管有重要的医学意义，但是寻找可以成像人体深部器官的光学非侵入性技术目前仍是一项公开任务。为了解决这个问题，由于高对比度和高空间分辨率等良好的特性，光声层析成像（PAT）在过去十年中受到了广泛的关注。但是，即使具有最佳组件，PAT也不能穿透几厘米，这仍然是该技术的重要局限性。在这里，我们计算PAT和超声断层扫描（UOT）的吸收对比水平，并将它们与相关的噪声源进行比较，作为成像深度的函数。结果表明，基于稀土离子晶体的光学滤波器的新发展可以使UOT技术明显领先于PAT。这样的滤光片可以使UOT的对比度噪声比在进入组织几厘米深处的PAT高达三个数量级。与PAT相比，它还可以显着增加UOT的图像深度，从而可以在人体中实时成像深部器官。此外，这样的光谱烧伤滤光片对来自组织的斑点去相关不敏感，并且可以在几乎任何入射光角度下工作，从而允许良好的光收集。我们从理论上证明了在非侵入式光学成像对人体心肌组织额叶的氧合水平的医学重要意义上的性能提高。我们的结果表明，有关UOT的进一步研究很有意义，并且该技术可能会对生物医学光学的未来方向产生重大影响。

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