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首页> 美国卫生研究院文献>Biomedical Optics Express >Use of a handheld terahertz pulsed imaging device to differentiate benign and malignant breast tissue
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Use of a handheld terahertz pulsed imaging device to differentiate benign and malignant breast tissue

机译：使用手持式太赫兹脉冲成像设备来区分乳腺的良性和恶性

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摘要

Since nearly 20% of breast-conserving surgeries (BCS) require re-operation, there is a clear need for developing new techniques to more accurately assess tumor resection margins intraoperatively. This study evaluates the diagnostic accuracy of a handheld terahertz pulsed imaging (TPI) system to discriminate benign from malignant breast tissue ex vivo. Forty six freshly excised breast cancer samples were scanned with a TPI handheld probe system, and histology was obtained for comparison. The image pixels on TPI were classified using (1) parameters in combination with support vector machine (SVM) and (2) Gaussian wavelet deconvolution in combination with Bayesian classification. The results were an accuracy, sensitivity, specificity of 75%, 86%, 66% for method 1, and 69%, 87%, 54% for method 2 respectively. This demonstrates the probe can discriminate invasive breast cancer from benign breast tissue with an encouraging degree of accuracy, warranting further study.
机译：由于将近20％的保乳手术（BCS）需要再次手术，因此显然需要开发新技术以在术中更准确地评估肿瘤切除边缘。这项研究评估了手持式太赫兹脉冲成像（TPI）系统的诊断准确性，以从体内区别良性和恶性乳房组织。用TPI手持式探针系统扫描了46个新鲜切除的乳腺癌样品，并获得了组织学进行比较。使用（1）参数结合支持向量机（SVM）和（2）高斯小波反卷积结合贝叶斯分类对TPI上的图像像素进行分类。结果是方法1的准确性，敏感性，特异性分别为75％，86％，66％，方法2的准确性，敏感性，特异性分别为69％，87％，54％。这表明该探针能够以令人鼓舞的准确度将浸润性乳腺癌与良性乳腺组织区别开来，值得进一步研究。

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