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首页> 美国卫生研究院文献>Bioinorganic Chemistry and Applications >Synthesis and Characterisation of Some New AluminiumDerivatives of Schiff Bases Containing N O and S DonorAtoms and the Anti Fertility Activity of the DerivativeAlSC6H4N:C(CH3)CH2COCH33
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Synthesis and Characterisation of Some New AluminiumDerivatives of Schiff Bases Containing N O and S DonorAtoms and the Anti Fertility Activity of the DerivativeAlSC6H4N:C(CH3)CH2COCH33

机译：几种新型铝的合成与表征含NO和S供体的Schiff碱的衍生物原子与衍生物的抗生育活性Al SC6H4N：C（CH3）CH2COCH3 3

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Some new compounds of aluminium having the general formula AI[SC6H4N:C(R) CH2 C(O)R’]3 where R = CH3, R' = CH3 (1); R' = CH3, R' = C6H5 (2); R = CF3, R’ = -C = CH - CH = CHS (3); R = CF3, R’ = C6H5 (4) have been synthesised by the reactions of Al(OPri)3 and the corresponding ligands in 1:3 molar ratios in benzene. Elemental and spectroscopic (IR, 1H, 13C, and 27AI NMR) characterisation of these monomeric compounds reveals monofunctional bidentate behaviour of ligand moiety and the octahedral geometry around aluminium atom. Compound (1), AI[SC6H4N:C(CH3)CH2COCH3], has been tested for its antifertility activity in male albino rats. The oral administration of this compound at the dose level 6.5 rag/rat/day reduced the weights of testes and epididymides. Significant decrease in sperm motility as well as sperm density resulted in the reduction of male fertility by 100%. Production of primary spermatocytes (preleptotene and pachytene), secondary spermatocytes and step-19 spermatids declined by 56.10%, 44.42 %, 63.35 % and 64.57 % respectively. These results indicate that the administration of compound (1) in male rats brought about an interference with spermatogenesis which ultimately caused infertility.
机译：一些具有通式AI [SC6H4N：C（R）CH2 C（O）R’] 3的铝的新化合物，其中R = CH3，R'= CH3（1）； R'= CH3，R'= C6H5（2）; R = CF3，R’= -C = CH-CH = CHS（3）；通过Al（OPr i ）3与相应的配体在苯中的摩尔比为1：3的反应，合成了R = CF3，R'= C6H5（4）。这些单体化合物的元素和光谱（IR， 1 H， 13 C和 27 Al NMR）表征揭示了配体部分的单官能双齿行为以及铝原子周围的八面体几何。测试了化合物（1）AI [SC6H4N：C（CH3）CH 2 COCH 3 ]在雄性白化病大鼠中的抗生育活性。以6.5 rag / rat / day的剂量口服该化合物可减少睾丸和附睾的重量。精子活力和精子密度的显着降低导致男性生育力降低了100％。原代精子细胞（prepeptetene和pachytene），次生精子细胞和step-19精子细胞的产量分别下降了56.10％，44.42％，63.35％和64.57％。这些结果表明，在雄性大鼠中施用化合物（1）对精子发生产生了干扰，最终导致了不育。

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