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首页> 美国卫生研究院文献>BioImpacts : BI >Preparation and characterization of biocomposite films of carrageenan/locust bean gum/montmorrillonite for transdermal delivery of curcumin
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Preparation and characterization of biocomposite films of carrageenan/locust bean gum/montmorrillonite for transdermal delivery of curcumin

机译：角叉菜胶/刺槐豆胶/蒙脱土用于姜黄素透皮递送的生物复合膜的制备和表征

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>Introduction: Skin can be used as a site for local and systemic drug administration. Diffusion of drugs through the skin has led to the development of different transdermal drug delivery systems. Curcumin is a wound healing and anti-inflammatory agent. Curcumin was incorporated into biocomposite films of carrageenan (κC)/locust bean gum (LBG)/ montmorillonite (MMT) prepared by a solvent casting method. >Methods: Film-forming solutions were prepared by adding and 2.5% v/v of propylene glycol and MMT (30% w/w). The curcumin loaded polymer composite transdermal films were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) spectroscopy and X-ray diffraction (XRD) analysis. Mechanical properties in terms of tensile strength and extensibility were studied. Films were also evaluated for moisture content, moisture uptake, thickness, folding endurance, swelling ratio and water vapor transmission rate (WVTR). >Results: κC and κC/L40 showed the highest percent cumulative release of 80.42±1.61% and 69.38±1.26% among all of the polymer composite transdermal films in 8 hours and 24 hours respectively. >Conclusion: In vitro release profiles showed that increasing concentration of LBG and MMT sustained the release of the drug from the polymer composite transdermal films. Decreased percent cumulative release as the concentration of LBG and MMT increases in polymer composite transdermal film.
机译：>简介：皮肤可以用作局部和全身给药的场所。药物通过皮肤的扩散导致了不同的透皮给药系统的发展。姜黄素是伤口愈合和抗炎药。将姜黄素掺入通过溶剂浇铸法制备的角叉菜胶（κC）/刺槐豆胶（LBG）/蒙脱石（MMT）的生物复合膜中。 >方法：通过添加2.5％v / v的丙二醇和MMT（30％w / w）制备成膜溶液。通过扫描电子显微镜（SEM），傅立叶变换红外光谱（FTIR）光谱和X射线衍射（XRD）分析来表征负载姜黄素的聚合物复合材料透皮薄膜。研究了抗拉强度和延伸性方面的机械性能。还评估了膜的水分含量，水分吸收，厚度，耐折性，溶胀率和水蒸气透过率（WVTR）。 >结果：在所有聚合物复合材料透皮薄膜中，κC和κC/ L40分别在8小时和24小时内的累积释放百分比最高，分别为80.42±1.61％和69.38±1.26％。 >结论：体外释放曲线表明，LBG和MMT浓度的增加使药物从聚合物复合材料透皮薄膜中释放出来。随着聚合物复合材料透皮薄膜中LBG和MMT浓度的增加，累积释放百分比降低。

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