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首页> 美国卫生研究院文献>Biochemical Journal >Metabolism of glucose in hyper- and hypo-thyroid rats in vivo. Minor role of endogenous insulin in thyroid-dependent changes in glucose turnover.
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Metabolism of glucose in hyper- and hypo-thyroid rats in vivo. Minor role of endogenous insulin in thyroid-dependent changes in glucose turnover.

机译：甲状腺功能亢进和甲状腺功能减退大鼠体内葡萄糖的代谢。内源性胰岛素在甲状腺依赖性葡萄糖代谢变化中的作用较小。

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1. Rates and rate coefficients of glucose utilization and replacement (glucose turnover) as well as its recycling were determined in rats by using [U-14C]- and [2-3H]-, [3-3H]- or [6-3H]-glucose. 2. In euthyroid rats, the blood concentration of glucose was 1.5 times and its turnover rate was 2 times as high in the fed state as in the starved state; consequently the rate coefficient, a measure of the capacity of rats to utilize blood glucose, was also higher in the former than in the latter. 3. Induction of mild diabetes by streptozotocin exerted little influence on the content and turnover of blood glucose in the starved state, whereas it caused hyperglycaemia and a decrease in the rate coefficient after feeding. 4. Induction of hyperthyroidism caused increases in rates and rate coefficients of glucose turnover to substantially the same extent whether or not the plasma concentration of insulin was lowered by treatment with streptozotocin or injection with anti-insulin serum. 5. It is concluded that thyroid hormones are capable of enhancing glucose turnover in the starved state independently of endogenous insulin, which plays a significant role in increasing glucose utilization in the fed state.
机译：1.使用[U-14C]-和[2-3H]-，[3-3H]-或[6-]确定大鼠中葡萄糖利用和置换（葡萄糖周转）及其循环的速率和速率系数3H]-葡萄糖。 2.在正常甲状腺大鼠中，进食状态下的血糖浓度是饥饿状态的1.5倍，周转率是饥饿状态的2倍；因此，前者的比率系数，即大鼠利用血糖能力的量度，也比后者高。 3.在饥饿状态下，链脲佐菌素诱导的轻度糖尿病对血糖的含量和周转几乎没有影响，而引起高血糖症和进食后速率系数降低。 4.甲状腺功能亢进的诱导引起的葡萄糖周转率和速率系数的增加基本上与通过用链脲佐菌素治疗或注射抗胰岛素血清降低胰岛素的血浆浓度基本相同的程度。 5.结论是，甲状腺激素能够在饥饿状态下独立于内源性胰岛素而提高葡萄糖转换，这在增加进食状态下的葡萄糖利用方面起着重要作用。

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