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首页> 外文期刊>The biochemical journal >Metabolism of glucose in hyper- and hypo-thyroid rats in vivo. Minor role of endogenous insulin in thyroid-dependent changes in glucose turnover
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Metabolism of glucose in hyper- and hypo-thyroid rats in vivo. Minor role of endogenous insulin in thyroid-dependent changes in glucose turnover

机译：体内超甲状腺大鼠葡萄糖的代谢。内源性胰岛素在葡萄糖周转中依赖于甲状腺依赖性变化的次要作用

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p1. Rates and rate coefficients of glucose utilization and replacement (glucose turnover) as well as its recycling were determined in rats by using [U-14C]- and [2-3H]-, [3-3H]- or [6-3H]-glucose. 2. In euthyroid rats, the blood concentration of glucose was 1.5 times and its turnover rate was 2 times as high in the fed state as in the starved state; consequently the rate coefficient, a measure of the capacity of rats to utilize blood glucose, was also higher in the former than in the latter. 3. Induction of mild diabetes by streptozotocin exerted little influence on the content and turnover of blood glucose in the starved state, whereas it caused hyperglycaemia and a decrease in the rate coefficient after feeding. 4. Induction of hyperthyroidism caused increases in rates and rate coefficients of glucose turnover to substantially the same extent whether or not the plasma concentration of insulin was lowered by treatment with streptozotocin or injection with anti-insulin serum. 5. It is concluded that thyroid hormones are capable of enhancing glucose turnover in the starved state independently of endogenous insulin, which plays a significant role in increasing glucose utilization in the fed state./p
机译：> 1。通过使用[U-14C] - 和[2-3H] - ，[3-3H] - 或[6-3H]在大鼠中确定葡萄糖利用和更换（葡萄糖周转）以及其再循环的速率和速率系数以及其再循环-葡萄糖。 2.在Euthyroid大鼠中，葡萄糖的血液浓度为1.5倍，其周转率为饥饿状态下的进料状态下的2倍;因此，在前者中，速率系数，大鼠使用血糖的能力的量度也比后者更高。 3.通过链脲佐菌素诱导轻度糖尿病对饥饿状态下血糖的含量和卷取的影响很小，而它引起高血糖血症和饲养后速率系数的降低。 4.甲状腺功能亢进的诱导引起的速度增加和血糖变换系数的增加，以基本相同的程度通过用链脲佐菌素或用抗胰岛素血清处理来降低胰岛素的血浆浓度。 5.得出结论，甲状腺激素能够独立于内源性胰岛素增强饥饿状态的葡萄糖周转，这在增加美联储状态下的葡萄糖利用方面发挥着重要作用。

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    《The biochemical journal》 |1979年第2期|共页
  • 作者

    F Okajima; M Ui;

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  • 收录信息 美国《科学引文索引》(SCI);
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