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首页> 美国卫生研究院文献>Biochemical Journal >Effects of aging on the responsiveness and sensitivity of glucose metabolism to insulin in the incubated soleus muscle isolated from Sprague-Dawley and Wistar rats.
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Effects of aging on the responsiveness and sensitivity of glucose metabolism to insulin in the incubated soleus muscle isolated from Sprague-Dawley and Wistar rats.

机译：衰老对从Sprague-Dawley和Wistar大鼠中分离出来的比目鱼肌肉中葡萄糖代谢对胰岛素的反应性和敏感性的影响。

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1. The effects of aging on the sensitivity and responsiveness of glucose transport, lactate formation and glycogen synthesis to insulin were studied in the incubated stripped soleus muscle isolated from aging Sprague-Dawley and Wistar rats. 2. As Sprague-Dawley rats aged from 5 to 13 weeks, there were marked increases in the concentrations of insulin that were required for half-maximal stimulation (i.e. EC50 value, which is a measure of sensitivity) of glucose transport, lactate formation and glycogen synthesis. 3. In marked contrast, there were no alterations in sensitivities of any of these processes to insulin in soleus muscle prepared from Wistar rats aged between 6 and 12 weeks. 4. However, in soleus muscles from 85-week-old Wistar rats the rates of glycogen synthesis in response to basal, sub-maximal and maximal concentrations of insulin were markedly decreased. The insulin EC50 value of glycogen synthesis was increased 4-fold, but was unchanged for lactate formation. 5. The insulin-stimulated rates of glucose transport in soleus muscles from 5- or 85-week-old Wistar rats were not significantly different.
机译：1.在从衰老的Sprague-Dawley和Wistar大鼠中分离出的经培养的比目鱼肌中，研究了衰老对葡萄糖转运，乳酸形成和糖原合成对胰岛素敏感性和响应性的影响。 2.随着Sprague-Dawley大鼠年龄从5周到13周的增长，葡萄糖转运，乳酸盐形成和半衰期的半数最大刺激（即EC50值，这是对敏感性的度量）所需的胰岛素浓度显着增加。糖原合成。 3.与之形成鲜明对比的是，从6至12周龄的Wistar大鼠制备的比目鱼肌中，这些过程对胰岛素的敏感性均无变化。 4.然而，在来自85周龄Wistar大鼠的比目鱼肌中，对基础，次最大和最大胰岛素浓度的糖原合成速率明显降低。糖原合成的胰岛素EC50值增加了4倍，但乳酸形成没有变化。 5. 5周或85周龄Wistar大鼠的比目鱼肌中胰岛素刺激的葡萄糖转运速率无显着差异。

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