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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Effects of age and anesthetic on plasma glucose and insulin levels and insulin sensitivity in spontaneously hypertensive and Wistar rats.
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Effects of age and anesthetic on plasma glucose and insulin levels and insulin sensitivity in spontaneously hypertensive and Wistar rats.

机译：年龄和麻醉剂对自发性高血压和Wistar大鼠血浆葡萄糖和胰岛素水平以及胰岛素敏感性的影响。

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摘要

We examined the effects of anesthetic, age, and strain on oral glucose tolerance tests (OGTT, 1 g/kg body weight) and intraperitoneal glucose tolerance tests (IPGTT, 2 g/kg body weight) in spontaneously hypertensive (SH) and Wistar rats. Pentobarbital anesthesia caused an elevation in basal glucose and insulin levels in Wistar rats at 9 and 16 weeks of age and in SH rats at 9 weeks. Anesthesia increased the insulin output during an OGTT in both strains of rats while glucose was unchanged. Anesthesia reduced the insulin sensitivity index calculated from the OGTT but not from the IPGTT data. The age of the rats (9-11 vs. 16-18 weeks) had no effect on the basal glucose or insulin levels, but older Wistar rats had a greater insulin output following oral glucose and older SH rats had a greater insulin output following intraperitoneal glucose. On the basis of the insulin sensitivity index, SH rats were clearly more insulin resistant than age-matched Wistar rats. The SH rats also had higher basal insulin levels, as well as higher insulin output, following both glucose challenges. In summary, SH rats are more insulin resistant than Wistar rats, and anesthesia, which elevated basal glucose and insulin levels and increased the insulin output in response to a glucose challenge, may increase insulin resistance.
机译：我们检查了麻醉剂，年龄和劳损对自发性高血压（SH）和Wistar大鼠的口服葡萄糖耐量测试（OGTT，1 g / kg体重）和腹膜内葡萄糖耐量测试（IPGTT，2 g / kg体重）的影响。戊巴比妥麻醉使Wistar大鼠在9周和16周龄以及SH大鼠在9周时基础葡萄糖和胰岛素水平升高。麻醉增加了两种大鼠在OGTT期间的胰岛素输出，而葡萄糖未改变。麻醉降低了从OGTT计算而得的胰岛素敏感性指数，但没有从IPGTT数据计算出。大鼠的年龄（9-11岁vs. 16-18周）对基础葡萄糖或胰岛素水平没有影响，但是较大的Wistar大鼠口服葡萄糖后有更高的胰岛素输出，而较大的SH大鼠腹膜内注射后有更大的胰岛素输出葡萄糖。根据胰岛素敏感性指数，SH大鼠明显比年龄匹配的Wistar大鼠更高。在两个葡萄糖激发之后，SH大鼠还具有较高的基础胰岛素水平以及较高的胰岛素输出。总而言之，SH大鼠比Wistar大鼠具有更高的胰岛素抵抗性，而麻醉会增加基础葡萄糖和胰岛素水平，并响应葡萄糖激发而增加胰岛素输出，因此可能会增加胰岛素抵抗。

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