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首页> 美国卫生研究院文献>The Journal of Neuroscience >Plane of Cell Cleavage and Numb Distribution during Cell Division Relative to Cell Differentiation in the Developing Retina
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Plane of Cell Cleavage and Numb Distribution during Cell Division Relative to Cell Differentiation in the Developing Retina

机译：相对于发育中的视网膜细胞分化的分裂过程中的细胞分裂平面和麻木分布

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Progenitor cells in the early developing nervous system can divide symmetrically, giving rise to two daughter cells that divide again, or asymmetrically, giving rise to one cell that differentiates and one that divides again. It has been suggested that the orientation of the cell cleavage plane during mitosis determines the type of division. A marker of early cell differentiation, the RA4 antigen, was used to identify regions of the developing chick retina with and without differentiating cells, and the orientation of the cleavage plane was characterized for mitotic figures in each region. No difference was found in the frequency of any orientation between the regions with or without differentiating cells. Furthermore, in the region of the retina with differentiating cells, the RA4 antigen was present in mitotic figures with every possible orientation. Thus, the orientation of the cleavage plane appears to be unrelated to whether or not a division produces a cell that differentiates. It has also been suggested that the intracellular protein Numb mediates neurogenesis via asymmetric localization during cell division. Numb localization was compared with expression of markers of early cell differentiation, the RA4 antigen and Delta. Differentiating and nondifferentiating cells were found both with and without Numb expression. Cells with a cleavage plane parallel to the retinal surface were polarized, such that Numb and/or the RA4 antigen, when present, were only in the daughter cell farthest from the ventricle. These findings indicate a need to reconsider current hypotheses regarding the key features underlying symmetric and asymmetric divisions in the developing nervous system.
机译：处于早期发育的神经系统中的祖细胞可以对称分裂，从而产生两个子细胞，它们又可以分裂，或者不对称，可以分化出一个细胞，然后又分裂。已经提出在有丝分裂期间细胞分裂平面的方向决定分裂的类型。早期细胞分化的标志物RA4抗原用于鉴定有或没有分化细胞​​的发育中雏鸡视网膜区域，并针对每个区域的有丝分裂图来表征切割平面的方向。在有或没有分化细胞​​的区域之间，任何取向的频率均未发现差异。此外，在具有分化细胞​​的视网膜区域中，RA4抗原以各种可能的方向存在于有丝分裂图中。因此，切割平面的方向似乎与分裂是否产生分化的细胞无关。还已经提出，细胞内蛋白Numb在细胞分裂过程中通过不对称定位介导神经发生。将麻木定位与早期细胞分化标志物，RA4抗原和Delta的表达进行比较。发现有和没有Numb表达的分化细胞和非分化细胞。将具有平行于视网膜表面的切割平面的细胞极化，这样，Numb和/或RA4抗原（如果存在）仅位于距离心室最远的子细胞中。这些发现表明有必要重新考虑有关正在发展的神经系统中对称和不对称分裂的关键特征的当前假设。

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