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首页> 外文期刊>The Journal of Comparative Neurology >Cell division and cleavage orientation in the developing retina are regulated by L-DOPA.
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Cell division and cleavage orientation in the developing retina are regulated by L-DOPA.

机译：发育中的视网膜中的细胞分裂和切割方向受L-DOPA调节。

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Recent studies have highlighted a potential link between the cleavage orientation of a dividing neuroblast and the regulation of daughter cell fate in the developing vertebrate retina. There is evidence to suggest that this process is at least partially regulated by the presence of the retinal pigment epithelium (RPE) and/or RPE-derived factors. In addition to a lack of melanin in the RPE, the albino retina is characterized by abnormal patterns of cell proliferation and cellular organization during development as well as cell-type specific deficits in the adult. We examined mitotic spindle orientation in vivo in developing pigmented and albino rat retinae along with other parameters of cell division to determine whether RPE abnormalities in the albino influence these aspects of retinal development. In the albino, mitotic indices were elevated, an excess of cells remained in the cell cycle, dividing cells were not so tightly apposed to the ventricular margin, and an excessive proportion of divisions wasvertically oriented (i.e., with the mitotic spindle aligned perpendicular to the plane of the neuroepithelium). Administration of L-DOPA (a melanin precursor found at reduced concentrations in the hypopigmented eye) regulated the distribution of spindle orientations and reduced levels of mitosis in a manner consistent with an endogenous role in the control of these processes. These findings highlight the multiple roles that L-DOPA plays in the regulation of retinal development and cast light on the diversity of anatomical abnormalities found in the albino visual system. J. Comp. Neurol. 496:369-381, 2006. (c) 2006 Wiley-Liss, Inc.
机译：最近的研究突出了正在分裂的成神经细胞的切割方向与发育中的脊椎动物视网膜中子代细胞命运的调控之间的潜在联系。有证据表明该过程至少部分受视网膜色素上皮（RPE）和/或RPE衍生因子的存在调节。除了RPE中缺乏黑色素外，白化病视网膜还具有发育过程中细胞增殖和细胞组织异常的模式以及成年后的细胞类型特异性缺陷。我们检查了色素沉着和白化病大鼠视网膜在体内的有丝分裂纺锤体定向以及其他细胞分裂参数，以确定白化病患者中的RPE异常是否影响视网膜发育的这些方面。在白化病中，有丝分裂指数升高，细胞周期中剩余细胞过多，分裂细胞未紧贴心室边缘，并且过度分裂的部分是垂直定向的（即，有丝分裂纺锤体垂直于神经上皮的平面）。 L-DOPA（在色素沉着的眼睛中浓度降低的黑色素前体）的施用以与控制这些过程中的内源性作用相一致的方式调节了纺锤取向的分布和有丝分裂水平的降低。这些发现凸显了L-DOPA在调节视网膜发育中的多种作用，并阐明了在白化病视觉系统中发现的解剖异常的多样性。 J.比较神经元。 496：369-381，2006.（c）2006 Wiley-Liss，Inc.

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