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首页> 美国卫生研究院文献>The Journal of Neuroscience >Multipolar Migration: The Third Mode of Radial Neuronal Migration in the Developing Cerebral Cortex
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Multipolar Migration: The Third Mode of Radial Neuronal Migration in the Developing Cerebral Cortex

机译：多极迁移：发展中的大脑皮层的径向神经元迁移的第三种模式。

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Two distinct modes of radial neuronal migration, locomotion and somal translocation, have been reported in the developing cerebral cortex. Although these two modes of migration have been well documented, the cortical intermediate zone contains abundant multipolar cells, and they do not resemble the cells migrating by locomotion or somal translocation. Here, we report that these multipolar cells express neuronal markers and extend multiple thin processes in various directions independently of the radial glial fibers. Time-lapse analysis of living slices revealed that the multipolar cells do not have any fixed cell polarity, and that they very dynamically extend and retract multiple processes as their cell bodies slowly move. They do not usually move straight toward the pial surface during their radial migration, but instead frequently change migration direction and rate; sometimes they even remain in almost the same position, especially when they are in the subventricular zone. Occasionally, the multipolar cells jump tangentially during their radial migration. Because the migration modality of these cells clearly differs from locomotion or somal translocation, we refer to their novel type of migration as “multipolar migration.” In view of the high proportion of cells exhibiting multipolar migration, this third mode of radial migration must be an important type of migration in the developing cortex.
机译：在发育中的大脑皮层中已经报道了径向神经元迁移的两种不同模式：运动和体位易位。尽管这两种迁移方式已得到充分证明，但皮质中间区包含丰富的多极细胞，它们与通过运动或体位迁移而迁移的细胞不相似。在这里，我们报告这些多极细胞表达神经元标记，并独立于放射状神经胶质纤维，在各个方向上扩展了多个薄过程。活切片的时移分析显示，多极细胞没有固定的细胞极性，并且随着细胞体的缓慢移动，它们可以非常动态地扩展和收缩多个过程。它们通常在径向迁移过程中并不直接朝向脑膜表面移动，而是经常改变迁移方向和速率。有时它们甚至保持几乎相同的位置，尤其是当它们位于心室下区域时。有时，多极细胞在其径向迁移过程中会切向跳跃。由于这些细胞的迁移方式明显不同于运动或体位转移，因此我们将其新型迁移称为“多极迁移”。鉴于表现出多极迁移的细胞比例很高，这种第三种径向迁移模式必须是发育中的皮层中的重要迁移类型。

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