• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>The Journal of Neuroscience >Neurotoxic Lesions of the Medial Mediodorsal Nucleus of the Thalamus Disrupt Reinforcer Devaluation Effects in Rhesus Monkeys
【2h】

Neurotoxic Lesions of the Medial Mediodorsal Nucleus of the Thalamus Disrupt Reinforcer Devaluation Effects in Rhesus Monkeys

机译：丘脑破坏增强器贬值作用的丘脑内侧中枢神经核的神经毒性病变。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The mediodorsal thalamus is a major input to the prefrontal cortex and is thought to modulate cognitive functions of the prefrontal cortex. Damage to the medial, magnocellular part of the mediodorsal thalamus (MDmc) impairs cognitive functions dependent on prefrontal cortex, including memory. The contribution of MDmc to other aspects of cognition dependent on prefrontal cortex has not been determined. The ability of monkeys to adjust their choice behavior in response to changes in reinforcer value, a capacity impaired by lesions of orbital prefrontal cortex, can be tested in a reinforcer devaluation paradigm. In the present study, rhesus monkeys with bilateral neurotoxic MDmc lesions were tested in the devaluation procedure. Monkeys learned visual discrimination problems in which each rewarded object is reliably paired with one of two different food rewards and then were given choices between pairs of rewarded objects, one associated with each food. Selective satiation of one of the food rewards reduces choices of objects associated with that food in normal monkeys. Monkeys with bilateral neurotoxic lesions of MDmc learned concurrently presented visual discrimination problems as quickly as unoperated control monkeys but showed impaired reinforcer devaluation effects. This finding suggests that the neural circuitry for control of behavioral choice by changes in reinforcer value includes MDmc.
机译：腹中丘脑是前额叶皮层的主要输入，被认为可调节额叶前皮层的认知功能。对中腹丘脑（MDmc）的内侧，诊断细胞部分的损害会损害取决于前额叶皮层的认知功能，包括记忆。 MDmc对取决于前额叶皮层的认知的其他方面的贡献尚未确定。可以在增强器贬值范式中测试猴子根据增强器值的变化来调节其选择行为的能力，该能力受眼眶前额叶皮层病变的损害。在本研究中，在贬值过程中测试了具有双侧神经毒性MDmc损伤的恒河猴。猴子学会了视觉辨别问题，其中每个奖励对象与两种不同食物奖励中的一种可靠地配对，然后在成对奖励对象之间进行选择，每对奖励对象与每种食物相关。对食物奖励之一的选择性满足减少了正常猴子中与该食物相关的对象的选择。患有MDmc的双侧神经毒性病变的猴子与未操作的对照组猴子同时出现视觉辨别问题，但增强剂贬值效果受损。这一发现表明，通过增强剂值的变化来控制行为选择的神经电路包括MDmc。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号