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首页> 美国卫生研究院文献>Journal of Ophthalmic Vision Research >Current Concepts of Oxygen Management in Retinopathy of Prematurity
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Current Concepts of Oxygen Management in Retinopathy of Prematurity

机译：早产儿视网膜病变中氧气管理的最新概念

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Retinopathy of prematurity (ROP) is a potentially blinding disorder in premature infants. The underlying pathophysiology is incompletely understood, limiting the prevention and treatment of this devastating condition. Current therapies are directed toward management of aberrant neovascularization thought to result from retinal ischemia in the developing preterm retina. The molecular mediators important for development of retinal ischemia and subsequent neovascular pathology are not fully understood. However, oxygen has been shown to be a key mediator of disease and the oxygen environment for preterm infants has been extensively studied. Despite this, the optimal oxygen environment for preterm infants remains unclear and recent works seeking to clarify this relationship demonstrate somewhat disparate findings. These data further substantiate that ROP is a complex disease with multifactorial etiology including genetic and environmental factors. Therefore, while environmental factors such as oxygen are important to our understanding of the disease process and care of preterm infants, identification of the molecular mediators downstream of oxygen which are necessary for development of ROP pathology will be critical to improve prevention, diagnosis and treatment strategies.
机译：早产儿视网膜病变（ROP）是早产儿的一种潜在的致盲性疾病。潜在的病理生理学尚未完全理解，限制了这种破坏性疾病的预防和治疗。当前的治疗方法是针对异常新生血管的处理，认为异常新生血管是由于发育中的早产儿视网膜缺血引起的。对于视网膜缺血和随后的新生血管病理发展重要的分子介体尚未完全了解。然而，氧气已被证明是疾病的关键介质，早产儿的氧气环境已得到广泛研究。尽管如此，对于早产儿的最佳氧气环境仍不清楚，并且最近为阐明这种关系而进行的研究显示出不同的发现。这些数据进一步证实了ROP是一种具有多种病因的复杂疾病，包括遗传和环境因素。因此，尽管氧气等环境因素对于我们了解疾病的过程和早产婴儿的护理很重要，但确定ROP病理发展所必需的氧气下游分子介体对于改善预防，诊断和治疗策略至关重要。 。

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