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Urinary excretion of B-group vitamins reflects the nutritional status ofB-group vitamins in rats

机译:B族维生素的尿液排泄反映了B族维生素的营养状况大鼠B组维生素

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摘要

We have reported previously that the urinary excretion of B-group vitamins reflects recent dietary intakes of these vitamins. We also proposed reference values for the urinary levels of B-group vitamins for human subjects, and used these for evaluating human nutritional status. However, the question arises as to whether the urinary excretion of B-group vitamins in animals or human subjects decreases immediately before they become B-group vitamin insufficient or when fed a diet low in vitamins. In the present study, rats were fed a vitamin-free diet for 5 d, and changes in the levels of B-group vitamins in urine and blood were monitored. Urinary excretion of vitamin B1, vitamin B2, 4-pyridoxic acid (a catabolite of vitamin B6), pantothenic acid, folate and biotin steeply decreased, and all of the values reached zero within 1–2 d. With respect to blood, the concentrations of only three of the eight B-group vitamins (vitamin B1, pyridoxal phosphate and biotin) decreased to 15 % (P < 0·0001), 7 % (P < 0·0001) and 2 % (P < 0·0001) on day 5, respectively, compared with the values at the beginning of the experiment. The decrease was more rapid and the changes were greater in the urine samples than in the blood samples. The present data complement our previous proposal that the urinary excretion of B-group vitamins reflects the nutritional status ofthese vitamins.
机译:先前我们已经报道过,B-族维生素的尿排泄反映了这些维生素最近的饮食摄入。我们还提出了人类受试者B组维生素尿水平的参考值,并将其用于评估人类的营养状况。但是,关于动物或人类中的B族维生素的尿排泄在它们变得不足为B族维生素之前或在进食低维生素饮食时是否会立即减少,这引起了问题。在本研究中,给大鼠喂了5天无维生素饮食,并监测了尿液和血液中B组维生素的水平变化。维生素B1,维生素B2、4-吡啶氧酸(维生素B6的分解代谢物),泛酸,叶酸和生物素的尿排泄量急剧下降,并且所有这些值在1-2天之内都达到零。就血液而言,八种B组维生素中的三种(维生素B1,磷酸吡ido醛和生物素)的浓度分别降至15%(P <0·0001),7%(P <0·0001)和2%将第5天的(P <0·0001)与实验开始时的值进行比较。尿液样品中的下降比血液样品中的下降更快,变化更大。目前的数据补充了我们先前的建议,即B类维生素的尿液排泄反映了维生素B的营养状况。这些维生素。

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