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首页> 美国卫生研究院文献>Avicenna Journal of Phytomedicine >Evaluation of anti-urolithiatic effect of aqueous extract of Bryophyllum pinnatum (Lam.) leaves using ethylene glycol-induced renal calculi
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Evaluation of anti-urolithiatic effect of aqueous extract of Bryophyllum pinnatum (Lam.) leaves using ethylene glycol-induced renal calculi

机译：乙二醇诱导的肾结石评价香茅叶水提取物的抗尿石症作用

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>Materials and Methods >: Thirty-six Wistar male rats were randomly divided into six equal groups. Group A animals received distilled water for 28 days. Group B to group F animals received 1% v/v ethylene glycol in distilled water for 28 days and group B served as ethylene glycol control. Groups C and D (preventive groups) received aqueous extract of leaves of B. pinnatum 50 and 100 mg/kg intraperitoneally, respectively for 28 days. Groups E and F (treatment groups) received aqueous extract of leaves of B. pinnatum 50 and 100 mg/kg intraperitoneally, respectively from 15th to 28th day. On days 0 and 28, 24 hrs urine samples were collected for urinary volume and urinary oxalate measurement. On day 28, blood was collected for serum creatinine and blood urea level monitoring. All animals were sacrificed and kidneys were removed, weighed, and histopathologically evaluated for calcium oxalate crystals deposition. Results: >Administration of aqueous extract of leaves of B. pinnatum reduced urine oxalate level >‎>significantly, as compared with Group B (p<0.001). Serum creatinine and blood urea level were >‎>improved significantly in all aqueous extract of leaves of B. pinnatum-treated groups. Relative >‎>kidney weight and calcium oxalate depositions were found significantly reduced in animals >‎>received ABP as compared with Group B (p<0.001). >‎Conclusions: B. pinnatum is effective in prevention and treatment of ethylene glycol-induced urolithiasis.
机译：>材料和方法 >：将36只Wistar雄性大鼠随机分为6组。 A组动物接受蒸馏水28天。 B组至F组动物在蒸馏水中接受1％v / v乙二醇，持续28天，B组作为乙二醇对照。 C组和D组（预防组）分别通过腹膜内注射50. 100和100 mg / kg的羽衣芽孢杆菌叶片的水提取物28天。 E组和F组（处理组）分别在第15天至第28天腹膜内接受了50. 100 mg / kg的松叶芥子的水提取物。在第0天和第28天，收集24小时的尿液样本用于尿量和草酸尿测定。在第28天，收集血液用于血清肌酐和血液尿素水平监测。处死所有动物，取出肾脏，称重，并在组织病理学上评估草酸钙晶体的沉积。结果：与B组相比，给予牛膝芽孢杆菌叶片水提取物降低尿草酸水平 > >显着。羽衣甘蓝处理组的所有叶片水提液中的血清肌酐和血尿素水平均得到了明显改善。 > > > >发现动物的肾脏重量和草酸钙沉积量显着降低 > >与B组相比，ABP降低了（p ＜0.001）。 > 结论：松果油杆菌在预防和治疗乙二醇引起的尿路结石症方面有效。

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