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首页> 美国卫生研究院文献>Asian-Australasian Journal of Animal Sciences >Effect of 24 h Fasting on Gene Expression of AMPK Appetite Regulation Peptides and Lipometabolism Related Factors in the Hypothalamus of Broiler Chicks
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Effect of 24 h Fasting on Gene Expression of AMPK Appetite Regulation Peptides and Lipometabolism Related Factors in the Hypothalamus of Broiler Chicks

机译：禁食24 h对肉仔鸡下丘脑AMPK基因表达食欲调节肽和脂肪代谢相关因子的影响

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摘要

The 5’-adenosine monophosphate-activated protein kinase (AMPK) is a key part of a kinase-signaling cascade that acts to maintain energy homeostasis. The objective of this experiment was to investigate the possible effects of fasting and refeeding on the gene expression of hypothalamic AMPK, some appetitive regulating peptides and lipid metabolism related enzymes. Seven-day-old male broiler (Arbor Acres) chicks were allocated into three equal treatments: fed ad libitum (control); fasted for 24 h; fasted for 24 h and then refed for 24 h. Compared with the control, the hypothalamic gene expression of AMPKα2, AMPKβ1, AMPKβ2, AMPKγ1, Ste20-related adaptor protein β (STRADβ), mouse protein 25α (MO25α) and agouti-related peptide (AgRP) were increased after fasting for 24 h. No significant difference among treatments was observed in mRNA levels of AMPKα1, AMPKγ2, LKB1 and neuropeptide Y (NPY). However, the expression of MO25β, pro-opiomelanocortin (POMC), corticotropin-releasing hormone (CRH), ghrelin, fatty acid synthase (FAS), acetyl-CoA carboxylase α (ACCα), carnitine palmitoyltransferase 1 (CPT-1) and sterol regulatory element binding protein-1 (SREBP-1) were significantly decreased. The present results indicated that 24 h fasting altered gene expression of AMPK subunits, appetite regulation peptides and lipometabolism related factors in chick’s hypothalamus; the hypothalamic FAS signaling pathway might be involved in the AMPK regulated energy homeostasis and/or appetite regulation in poultry.
机译：5'-腺苷单磷酸激活蛋白激酶（AMPK）是激酶信号级联反应的关键部分，可维持能量稳态。该实验的目的是研究禁食和再喂食对下丘脑AMPK基因表达，某些食性调节肽和脂质代谢相关酶的可能影响。将7天大的雄性肉鸡（Arbor Acres）小鸡分配给三种相同的处理方法：随意进食（对照）；幼仔（对照）；幼仔（对照）。禁食24小时；禁食24小时，然后禁食24小时。与对照组相比，禁食24 h后AMPKα2，AMPKβ1，AMPKβ2，AMPKγ1，Ste20相关衔接蛋白β（STRADβ），小鼠蛋白25α（MO25α）和刺骨相关肽（AgRP）下丘脑基因表达增加。 AMPKα1，AMPKγ2，LKB1和神经肽Y（NPY）的mRNA水平在治疗之间未见显着差异。然而，MO25β，促黑素皮质激素原（POMC），促肾上腺皮质激素释放激素（CRH），生长素释放肽，脂肪酸合酶（FAS），乙酰辅酶A羧化酶α（ACCα），肉碱棕榈酰转移酶1（CPT-1）和固醇的表达调节元件结合蛋白-1（SREBP-1）明显减少。目前的研究结果表明，禁食24小时改变了鸡下丘脑中AMPK亚基，食欲调节肽和脂肪代谢相关因子的基因表达。下丘脑FAS信号通路可能参与家禽的AMPK调节能量稳态和/或食欲调节。

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