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首页> 美国卫生研究院文献>Asian Journal of Andrology >Ex vivo relaxation effect of Cuscuta chinensis extract on rabbit corpus cavernosum
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Ex vivo relaxation effect of Cuscuta chinensis extract on rabbit corpus cavernosum

机译：s草提取物对兔海绵体的离体舒张作用

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摘要

The effect of Cuscuta chinensis extract on the rabbit penile corpus cavernosum (PCC) was evaluated in the present study. Penises obtained from healthy male New Zealand white rabbits (2.5–3.0 kg) were precontracted with phenylephrine (Phe, 10 µmol l−1) and then treated with various concentrations of Cuscuta chinensis extract (1, 2, 3, 4 and 5 mg ml−1). The change in penile tension was recorded, and cyclic nucleotides in the PCC were measured by radioimmunoassay (RIA). The interaction between Cuscuta chinensis and sildenafil was also evaluated. The result indicated that the PCC relaxation induced by Cuscuta chinensis extract was concentration-dependent. Pre-treatment with an nitric oxide synthase (NOS) inhibitor (Nω nitro-L-arginine-methyl ester, L-NAME), a guanylyl cyclase inhibitor (1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one, ODQ), or a protein kinase A inhibitor (KT 5720) did not completely inhibit the relaxation. Incubation of penile cavernous tissue with the Cuscuta chinensis extract significantly increased cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP) in the PCC. Moreover, the Cuscuta chinensis extract significantly enhanced sildenafil-induced PCC relaxation. In conclusion, the Cuscuta chinensis extract exerts a relaxing effect on penile cavernous tissue in part by activating the NO-cGMP pathway, and it may improve erectile dysfunction (ED), which does not completely respond to sildenafil citrate.
机译：在本研究中评估了s草提取物对兔阴茎海绵体（PCC）的作用。用苯肾上腺素（Phe，10 µmol l -1 ）预收缩从健康的雄性新西兰白兔（2.5-3.0 kg）获得的阴茎，然后用各种浓度的中华s提取物处理（1，2， 3、4和5 mg ml -1 ）。记录阴茎张力的变化，并通过放射免疫测定法（RIA）测量PCC中的环状核苷酸。还评估了中华Cu和西地那非之间的相互作用。结果表明，中华Cu提取物引起的PCC松弛是浓度依赖性的。用一氧化氮合酶（NOS）抑制剂（Nω硝基-L-精氨酸甲酯，L-NAME），鸟苷酸环化酶抑制剂（1H- [1,2,4]恶二唑[4,3-a]进行预处理喹喔啉-1-酮（ODQ）或蛋白激酶A抑制剂（KT 5720）不能完全抑制松弛。用Cuscuta chinensis提取物孵育阴茎海绵状组织可显着增加PCC中的环状鸟苷单磷酸酯（cGMP）和环状腺苷单磷酸酯（cAMP）。此外，中华s丝提取物显着增强了西地那非诱导的PCC松弛。总之，Cuscuta chinensis提取物部分地通过激活NO-cGMP途径对阴茎海绵体组织产生松弛作用，并且可能改善勃起功能障碍（ED），而勃起功能障碍不能完全响应柠檬酸西地那非。

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