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首页> 美国卫生研究院文献>Asian Journal of Andrology >A population study of fasting time and serum prostate-specific antigen (PSA) level
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A population study of fasting time and serum prostate-specific antigen (PSA) level

机译：禁食时间和血清前列腺特异性抗原（PSA）水平的人群研究

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Prostate cancer is one of the most common cancers in men. Traditional screening and diagnostic methods include digital rectal examinations (DREs), biopsies and serum prostate-specific antigen (PSA) tests, with the latter being the more popular. PSA is a biomarker for prostate cancer; however, it is highly sensitive to external factors as well as other prostate diseases. As such, the reliability of of the serum PSA level as a sole screening and diagnostic tool for prostate cancer is controversial. Recently, it has been shown that fasting extremes can affect concentrations of serum chemistry analytes, thus raising the question of whether or not fasting has an effect on the highly sensitive PSA biomarker. Patients testing for serum PSA levels are often concomitantly submitting to other tests that require fasting, subjecting certain patients to a fasting PSA level while others not. The objective of this study was to investigate whether this discrepancy in fasting state translates into an effect on serum PSA levels. Serum PSA levels and fasting time records for 157 276 men who underwent testing at Calgary Laboratory Services (CLS; Calgary, Alberta, Canada) between 01 January 2010 and 31 March 2013 were accessed. Linear regression models of mean PSA levels and fasting times revealed a statistically important relationship at certain fasting times. Applying a dynamic mathematical model to explore the clinical effect of fasting suggests minimal impact on serum PSA result interpretation. Thus, patients can be tested for serum PSA levels regardless of their fasting state.
机译：前列腺癌是男性中最常见的癌症之一。传统的筛查和诊断方法包括直肠指检（DRE），活检和血清前列腺特异性抗原（PSA）检测，后者更为流行。 PSA是前列腺癌的生物标志物；但是，它对外部因素以及其他前列腺疾病高度敏感。这样，血清PSA水平作为前列腺癌唯一的筛查和诊断工具的可靠性是有争议的。最近，已经表明，极端的禁食会影响血清化学分析物的浓度，从而提出禁食是否对高度敏感的PSA生物标志物产生影响的问题。患者血清PSA水平的检测通常伴随着需要禁食的其他检查，使某些患者处于禁食PSA水平，而其他患者则不需要。这项研究的目的是调查这种禁食状态的差异是否会转化为对血清PSA水平的影响。查阅了2010年1月1日至2013年3月31日期间在卡尔加里实验室服务中心（CLS；加拿大艾伯塔省卡尔加里）进行测试的157276名男性的血清PSA水平和禁食时间记录。平均PSA水平和禁食时间的线性回归模型显示，在某些禁食时间，统计学上重要的关系。应用动态数学模型探索禁食的临床效果表明，对血清PSA结果解释的影响最小。因此，可以测试患者的血清PSA水平，而不管其禁食状态如何。

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