首页> 美国卫生研究院文献>Antimicrobial Agents and Chemotherapy >Comparative penetration of azlocillin and mezlocillin into cerebrospinal fluid of normal rabbits and rabbits with experimentally induced Pseudomonas aeruginosa meningitis.
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Comparative penetration of azlocillin and mezlocillin into cerebrospinal fluid of normal rabbits and rabbits with experimentally induced Pseudomonas aeruginosa meningitis.

机译:比较azlocillin和mezlocillin渗透到正常兔和实验诱发的铜绿假单胞菌脑膜炎兔的脑脊液中。

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摘要

The impacts of meningeal infection with Pseudomonas aeruginosa and route of drug administration on the penetration of azlocillin and mezlocillin into the cerebrospinal fluid of rabbits were evaluated. The penetration of both agents was increased to a similar degree in rabbits with meningitis compared with normal rabbits. The increase in penetration was greater after intravenous administration than after intramuscular administration.
机译:评估了铜绿假单胞菌脑膜感染和药物给药途径对阿奇洛林和美洛西林渗透兔脑脊液的影响。与正常兔子相比,两种药物在脑膜炎兔子中的渗透率均增加了相似的程度。静脉内给药后的渗透增加比肌肉内给药后更大。

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