Synthesis and antimicrobial activity of a series of caespitin derivatives.

机译：一系列caespitin衍生物的合成和抗菌活性。

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

Chemical modification of the naturally occurring phlorophenone antimicrobial agent caespitin is described. These modifications include variations in the phenone side chain, substitution with prenyl, allyl, and benzyl in the 4-position of the phlorophenone nucleus, and ring cyclizations via etherification to give furan and chroman compounds. Several of these derivatives show enhanced in vitro potency over caespitin. Studies on the development of microbial resistance against these compounds show that no or very little resistance developed after several passes of these compounds in representative microbial strains.

机译：描述了天然存在的苯甲酮抗微生物剂caespitin的化学修饰。这些修饰包括苯乙酮侧链的变化，苯乙酮核的4-位被异戊烯基，烯丙基和苄基取代，以及通过醚化进行环化以生成呋喃和苯并二氢吡喃化合物。这些衍生物中的几种表现出比caespitin更高的体外效能。对这些化合物的微生物抗性发展的研究表明，在代表性微生物菌株中这些化合物经过数次通过后，没有或几乎没有产生抗性。

著录项

期刊名称 Antimicrobial Agents and Chemotherapy
作者
C J Van der Schyf; T G Dekker; T G Fourie; F O Snyckers;
展开▼
作者单位

展开▼
年(卷),期 1986(30),3
年度 1986
页码 375–381
总页数 7
原文格式 PDF
正文语种
中图分类药学;微生物学;
关键词

相似文献

外文文献
中文文献
专利

1. Hydrogen bonding chains and rings structural motifs in new series of N-phthaloyl aminocarboxylic acid derivatives. Solid state microwave synthesis, structural chemistry, computational calculations and antimicrobial activity [J] . Al-Farhan K., Ghazzali M., Al-Hazimi H.M.A., Journal of Molecular Structure . 2011,第1a3期

机译：新系列的N-邻苯二甲酰基氨基羧酸衍生物中的氢键链和环结构基序。固态微波合成，结构化学，计算计算和抗菌活性
2. Synthesis and antimicrobial activity of some novel derivatives of benzofuran: Part 2. The synthesis and antimicrobial activity of some novel 1-(1-benzofuran-2-yl)-2-mesitylethanone derivatives. [J] . Kirilmis C, Ahmedzade M, Servi S, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2008,第2期

机译：某些新颖的苯并呋喃衍生物的合成和抑菌活性：第2部分。某些新颖的1-（1-苯并呋喃-2-基）-2-间苯二甲酮衍生物的合成和抑菌活性。
3. Synthesis and antimicrobial activity of some novel derivatives of benzofuran: part 1. Synthesis and antimicrobial activity of (benzofuran-2-yl)(3-phenyl-3-methylcyclobutyl) ketoxime derivatives. [J] . Koca M, Servi S, Kirilmis C, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2005,第12期

机译：某些新型苯并呋喃衍生物的合成和抑菌活性：第1部分。（苯并呋喃-2-基）（3-苯基-3-甲基环丁基）酮肟衍生物的合成和抑菌活性。
4. Synthesis and toxicological activity of 5-nitroindazole sulfonamides derivatives as potential antimicrobial agents. Optimization of the synthesis [C] . Corina Cheptea, Andreea-Celia Benchea, Marius Găină, 2017 E-Health and Bioengineering Conference . 2017

机译：5-硝基吲唑磺酰胺衍生物作为潜在抗菌剂的合成及其毒理活性。优化合成
5. X-ray Crystallographic Investigations Ab-initio Calculations and Antimicrobial Activities of significant N-heterocycles and Chalcone Derivatives. [D] . Gandhi, Sahajkumar A. 2014

机译：X射线晶体学研究重要的N杂环和查耳酮衍生物的从头算和抗菌活性。
6. Synthesis and Antimicrobial Activity of a New Series of Thiazolidine-24-diones Carboxamide and Amino Acid Derivatives [O] . Rakia Abd Alhameed, Zainab Almarhoon, Sarah I. Bukhari, 2020

机译：新型噻唑烷-24-二酮羧酰胺和氨基酸衍生物的合成及抑菌活性
7. Synthesis and antimicrobial activity of a series of caespitin derivatives. [O] . Van der Schyf, C J, Dekker, T G, Fourie, T G, 1986

机译：一系列caespitin衍生物的合成和抗菌活性。

Synthesis and antimicrobial activity of a series of caespitin derivatives.

摘要

著录项

相似文献

相关主题

期刊订阅