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Note: Low Plasma Cefepime Levels in Critically Ill Septic Patients: Pharmacokinetic Modeling Indicates Improved Troughs with Revised Dosing

机译：注意：重症脓毒症患者的血浆头孢吡肟水平较低：药代动力学模型表明通过调整剂量可以改善食槽

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The pharmacokinetics of a 2-g bolus of cefepime were measured in critically ill patients with normal renal function. Variable and low trough plasma drug concentrations were found, and 8 of 10 patients had levels below the MIC at which 50% of the isolates are inhibited for Pseudomonas aeruginosa. Computer simulations predicted that continuous infusion and shorter dosing intervals would increase trough levels.

机译：在肾功能正常的危重患者中测量了2 g头孢吡肟大剂量的药代动力学。发现血浆药物浓度低且低，并且10名患者中有8名的水平低于MIC，在该水平下50％的分离物对铜绿假单胞菌具有抑制作用。计算机模拟预测，连续输液和较短的给药间隔将增加谷水平。

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期刊名称 Antimicrobial Agents and Chemotherapy
作者
J. Lipman; S. C. Wallis; C. Rickard;
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作者单位

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年(卷),期 1999(43),10
年度 1999
页码 2559–2561
总页数 3
原文格式 PDF
正文语种
中图分类药学;微生物学;
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专利

1. Low plasma cefepime levels in critically ill septic patients: pharmacokinetic modeling indicates improved troughs with revised dosing. [J] . Lipman J, Wallis SC, Rickard C Antimicrobial agents and chemotherapy. . 1999,第10期

机译：重症脓毒症患者的血浆头孢吡肟水平低：药代动力学模型表明，通过调整剂量可以改善药谷。
2. Low cefpirome levels during twice daily dosing in critically ill septic patients: pharmacokinetic modelling calls for more frequent dosing. [J] . Lipman J, Wallis SC, Rickard CM, Intensive care medicine . 2001,第2期

机译：重症脓毒症患者每天两次给药期间的头孢哌酮水平低：药代动力学模型要求更频繁的给药。
3. Low cefpirome levels during twice daily dosing in critically ill septic patients: pharmacokinetic modelling calls for more frequent dosing. [J] . Lipman J, Wallis SC, Rickard CM, Intensive care medicine . 2001,第2期

机译：重症脓毒症患者每天两次给药期间的头孢哌酮水平低：药代动力学模型要求更频繁的给药。
4. Optimization under uncertainty of melatonin dosing for critically ill patients [C] . Adriana Savoca, Giuseppe Pesenti, Davide Manca European Symposium on Computer Aided Chemical engineering . 2019

机译：临床病患者褪黑素给药不确定性下的优化
5. Clinical pharmacokinetic simulation/modeling as a tool for therapeutic drug monitoring and dose adjustment in special patient populations. [D] . Mohamed, Osama H. 2004

机译：临床药代动力学模拟/建模，作为特殊患者人群中治疗药物监测和剂量调整的工具。
6. Population Pharmacokinetics and Target Attainment of Cefepime in Critically Ill Patients and Guidance for Initial Dosing [O] . Mohammad H. Al-Shaer, Michael N. Neely, Jiajun Liu, 2020

机译：人口药代动力学和目标在重症病患者中的头孢台和初始给药的指导
7. Low plasma cefepime levels in critically ill septic patients: pharmacokinetic modelling indicates improved troughs with revised dosing [O] . Lipman J, Wallis SC, Rickard C 1999

机译：重症脓毒症患者血浆头孢吡肟水平低：药代动力学模型表明，通过调整剂量可以改善药谷

Note: Low Plasma Cefepime Levels in Critically Ill Septic Patients: Pharmacokinetic Modeling Indicates Improved Troughs with Revised Dosing

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