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首页> 美国卫生研究院文献>Antimicrobial Agents and Chemotherapy >Susceptibilities of Mycoplasma hominis M. pneumoniae and Ureaplasma urealyticum to GAR-936 Dalfopristin Dirithromycin Evernimicin Gatifloxacin Linezolid Moxifloxacin Quinupristin-Dalfopristin and Telithromycin Compared to Their Susceptibilities to Reference Macrolides Tetracyclines and Quinolones
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Susceptibilities of Mycoplasma hominis M. pneumoniae and Ureaplasma urealyticum to GAR-936 Dalfopristin Dirithromycin Evernimicin Gatifloxacin Linezolid Moxifloxacin Quinupristin-Dalfopristin and Telithromycin Compared to Their Susceptibilities to Reference Macrolides Tetracyclines and Quinolones

机译：人参支原体肺炎支原体和解脲脲原体对GAR-936达福普汀地利霉素Evernimicin加替沙星利奈唑胺莫西沙星奎奴普林汀-达福普汀和四氢大环孢菌素四环霉素和四环霉素的敏感性

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摘要

The susceptibilities of Mycoplasma hominis, Mycoplasma pneumoniae, and Ureaplasma urealyticum to eight new antimicrobial agents were determined by agar dilution. M. pneumoniae was susceptible to the new glycylcycline GAR-936 at 0.12 μg/ml and evernimicin at 4 μg/ml, but it was resistant to linezolid. It was most susceptible to dirithromycin, quinupristin-dalfopristin, telithromycin, reference macrolides, and josamycin. M. hominis was susceptible to linezolid, evernimicin, and GAR-936. It was resistant to macrolides and the ketolide telithromycin but susceptible to quinupristin-dalfopristin and josamycin. U. urealyticum was susceptible to evernimicin (8 to 16 μg/ml) and resistant to linezolid. It was less susceptible to GAR-936 (4.0 μg/ml) than to tetracycline (0.5 μg/ml). Telithromycin and quinupristin-dalfopristin were the most active agents against ureaplasmas (0.06 μg/ml). The new quinolone gatifloxacin was active against M. pneumoniae and M. hominis at 0.12 to 0.25 μg/ml and active against ureaplasmas at 1.0 μg/ml. The MICs of macrolides were markedly affected by pH, with an 8- to 32-fold increase in the susceptibility of M. pneumoniae as the pH increased from 6.9 to 7.8. A similar increase in susceptibility with increasing pH was also observed with ureaplasmas. Tetracyclines showed a fourfold increase of activity as the pH decreased 1 U, whereas GAR-936 showed a fourfold decrease in activity with a decrease in pH.
机译：用琼脂稀释法测定人型支原体，肺炎支原体和解脲支原体对八种新抗菌药的敏感性。肺炎支原体对0.12μg/ ml的新糖基环素GAR-936和4μg/ ml的依维尼星敏感，但对利奈唑胺有抗药性。它最易受地红霉素，奎奴普丁-达福普汀，替利霉素，参考大环内酯类和交沙霉素的影响。人型支原体对利奈唑胺，evernimicin和GAR-936敏感。它对大环内酯类和酮内酯泰利霉素有抗性，但对奎奴普丁-达福普汀和若沙霉素敏感。解脲脲原体对evernimicin（8至16μg/ ml）敏感，对利奈唑胺有抗药性。它对GAR-936（4.0μg/ ml）的敏感性低于对四环素（0.5μg/ ml）的敏感性。 Telithromycin和quinupristin-dalfopristin是抗脲原体活性最高的药物（0.06μg/ ml）。新的喹诺酮加替沙星对肺炎支原体和人型支原体的活性为0.12至0.25μg/ ml，对脲原体的活性为1.0μg/ ml。大环内酯类化合物的MIC受到pH的显着影响，随着pH从6.9增加到7.8，肺炎支原体的敏感性增加了8到32倍。对于脲原体，还观察到敏感性随pH升高而增加。四环素显示随着pH值降低1 U而活性增加四倍，而GAR-936显示随pH值降低四倍。

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