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Activity of Moxifloxacin Imipenem and Ertapenem against Escherichia coli Enterobacter cloacae Enterococcus faecalis and Bacteroides fragilis in Monocultures and Mixed Cultures in an In Vitro Pharmacokinetic/Pharmacodynamic Model Simulating Concentrations in the Human Pancreas

机译：莫西沙星亚胺培南和厄他培南在模拟人胰脏中浓度的体外药代动力学/药效学模型的单培养和混合培养中对大肠杆菌阴沟肠杆菌粪肠球菌和脆弱拟杆菌的活性

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The activities of moxifloxacin, imipenem, and ertapenem against pathogens causing severe necrotizing pancreatitis were studied in an in vitro pharmacokinetics/pharmacodynamics (PK/PD) model. Escherichia coli, Enterobacter cloacae, Enterococcus faecalis, and Bacteroides fragilis were exposed in monocultures and mixed cultures to concentrations of the three agents comparable to those in the human pancreas. Moxifloxacin was more active than the two carbapenems in monocultures and mixed cultures, reducing the numbers of CFU more drastically and more rapidly.

机译：在体外药代动力学/药效学（PK / PD）模型中研究了莫西沙星，亚胺培南和厄他培南对引起严重坏死性胰腺炎的病原体的活性。大肠杆菌，泄殖腔肠杆菌，粪肠球菌和脆弱拟杆菌分别在单培养和混合培养中暴露于与人类胰腺相当的三种药物浓度。在单一培养和混合培养中，莫西沙星比两种碳青霉烯类更具活性，从而更迅速，更迅速地减少了CFU的数量。

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期刊名称 Antimicrobial Agents and Chemotherapy
作者
Sabine Schubert; Axel Dalhoff;
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年(卷),期 2012(56),12
年度 2012
页码 6434–6436
总页数 3
原文格式 PDF
正文语种
中图分类药学;微生物学;
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1. Activity of moxifloxacin, imipenem, and ertapenem against Escherichia coli, Enterobacter cloacae, Enterococcus faecalis, and Bacteroides fragilis in monocultures and mixed cultures in an in vitro pharmacokinetic/pharmacodynamic model simulating concentrations in the human pancreas [J] . SchubertS., DalhoffA. Antimicrobial agents and chemotherapy. . 2012,第12期

机译：在体外药代动力学/药效学模型中模拟人类胰腺中的浓度，莫西沙星，亚胺培南和厄他培南在单培养和混合培养中对大肠杆菌，阴沟肠杆菌，粪肠球菌和脆弱拟杆菌的活性
2. In vitro bactericidal activity of piperacillin, gentamicin, and metronidazole in a mixed model containing Escherichia coli, Enterococcus faecalis, and Bacteroides fragilis. [J] . Pendland SL, Jung R, Messick CR, Diagnostic microbiology and infectious disease . 2002,第2期

机译：在包含大肠杆菌，粪肠球菌和脆弱拟杆菌的混合模型中，哌拉西林，庆大霉素和甲硝唑的体外杀菌活性。
3. In vitro activity of trovafloxacin against Bacteroides fragilis in mixed culture with either Escherichia coli or a vancomycin- resistant strain of Enterococcus faecium determined by an anaerobic time-kill technique. [J] . Stearne LE, Kooi C, Goessens WH, Antimicrobial agents and chemotherapy. . 2001,第1期

机译：在与大肠杆菌或粪便肠球菌耐万古霉素的菌株混合培养物中，用厌氧时间杀灭技术测定曲伐沙星对脆弱拟杆菌的体外活性。
4. Levofloxacin plus Metronidazole Administered Once Daily versus Moxifloxacin Monotherapy against a Mixed Infection of Escherichia coli and Bacteroides fragilis in an In Vitro Pharmacodynamic Model [O] . Elizabeth D. Hermsen, Laurie B. Hovde, Kelly A. Sprandel, 2005

机译：左氧氟沙星加甲硝唑每日一次与莫西沙星单一疗法在体外药效学模型中对大肠杆菌和脆弱拟杆菌的混合感染进行比较
5. Activity of moxifloxacin against Bacteroides fragilis and Escherichia coli in an in vitro pharmacokinetic/pharmacodynamic model employing pure and mixed cultures [O] . Reiner Schaumann, Ellie JC Goldstein, Jochen Forberg, 2005

机译：艾灸氧化嘧啶对植物药代动力学/药物动力学模型中的菌株脆弱和大肠杆菌的活性，纯化培养物

Activity of Moxifloxacin Imipenem and Ertapenem against Escherichia coli Enterobacter cloacae Enterococcus faecalis and Bacteroides fragilis in Monocultures and Mixed Cultures in an In Vitro Pharmacokinetic/Pharmacodynamic Model Simulating Concentrations in the Human Pancreas

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