首页> 美国卫生研究院文献>Annals of the Rheumatic Diseases >Change of prostaglandin E level in joint fluids after treatment with flurbiprofen in patients with rheumatoid arthritis and osteoarthritis.
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Change of prostaglandin E level in joint fluids after treatment with flurbiprofen in patients with rheumatoid arthritis and osteoarthritis.

机译:类风湿关节炎和骨关节炎患者用氟比洛芬治疗后关节液中前列腺素E水平的变化。

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摘要

The prostaglandin E (PGE) level in the knee joint fluid was determined by radioimmunoassay before and after anti-inflammatory therapy with flurbiprofen in 8 patients with rheumatoid arthritis (RA) and 4 patients with osteoarthritis (OA). The level of PGE in RA joint fluids before the anti-inflammatory treatment was 9.5-1.2 ng/ml and in proportion with the leucocyte count in the joint fluid. A marked decrease of the PGE level was attained with flurbiprofen treatment in 4 patients whose initial PGE levels had been higher than 3.2 ng/ml, while 4 patients with lower PGE levels, namely, 1.4-1.2 ng/ml, did not respond to the drug treatment. In all the OA patients the PGE levels was no higher than 1.5 ng/ml and refractory to the anti-inflammatory therapy.
机译:在8名类风湿关节炎(RA)和4例骨关节炎(OA)患者中,用氟比洛芬进行抗炎治疗前后,通过放射免疫测定法测定了膝关节液中前列腺素E(PGE)的水平。抗炎治疗前,RA关节液中PGE的水平为9.5-1.2 ng / ml,并与关节液中的白细胞计数成正比。氟比洛芬治疗使4例初始PGE水平高于3.2 ng / ml的患者的PGE水平明显降低,而4例PGE水平较低的患者,即1.4-1.2 ng / ml,对PGE水平无反应。药物治疗。在所有OA患者中,PGE水平均不高于1.5 ng / ml,并且抗炎治疗无效。

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