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Multicentric reticulohistiocytosis: a rare cause of erosive arthropathy of the distal interphalangeal finger joints

机译:多中心网状组织细胞增生:指间远端手指关节糜烂性关节炎的罕见原因

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摘要

Case report: A case of MRH arthropathy, in which the typical nodular skin manifestation of the disease was absent, is described in a patient with a past history of breast cancer and no evidence of recurrent or new malignancy. Results: Careful clinical and roentgenological evaluation disclosed important clues to differentiate this condition from other more common distal interphalangeal arthritides—namely, osteoarthritis and its "erosive" variant, rheumatoid arthritis, psoriatic arthritis, tophaceous gout, dialysis related hand arthropathy, and from the rarer fibroblastic rheumatism, all of which can be mimicked by MRH. Histopathology showed the characteristic histiocytic and multinucleated giant cell infiltrate with ground glass cytoplasm, and immunohistochemical analysis showed markers evocative of a monocyte/macrophage origin of MRH.
机译:病例报告:一名患有乳腺癌的既往史患者,没有复发或新发恶性肿瘤的患者,其中描述了没有该疾病典型结节性皮肤表现的MRH关节炎病例。结果:仔细的临床和X线检查评估揭示了重要的线索,可以将这种状况与其他较常见的远端指间关节炎(即骨关节炎及其“侵蚀性”变体,类风湿性关节炎,银屑病关节炎,痛风性痛风,透析相关的手关节炎)以及罕见病区别开来。纤维化风湿病,所有这些都可以由MRH模仿。组织病理学显示特征性组织细胞和多核巨细胞浸润有磨碎的玻璃细胞质,免疫组织化学分析显示标志物可唤起MRH的单核细胞/巨噬细胞起源。

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