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γδ T cell subsets in patients with arthritis and chronic neutropenia

机译：关节炎和慢性中性粒细胞减少症患者的γδT细胞亚群

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摘要

Background: An abnormal distribution of subsets of γδ T cells, which are a component of the inflammatory infiltrate in arthritic synovium, has been demonstrated in the peripheral blood (PB) of patients with arthritis and neutropenia. Objective: To evaluate whether the clinical manifestations of patients with arthritis and neutropenia are related to the specific γδ T cell subset predominant in the PB. Methods: Flow cytometry of PB lymphocytes in six consecutive patients with chronic neutropenia and arthritis was performed. Variable (V) γ and δ gene families were analysed by polymerase chain reaction. cDNA was subjected to direct automated sequencing of T cell receptor (TCR) genes. Results: Three patients had non-deforming and non-erosive rheumatoid factor (RF)+ polyarticular rheumatoid arthritis, RF+ oligoarticular arthritis, or RF- non-deforming oligoarticular psoriatic arthritis with persistent expansions of Vγ1+/Vδ2+, Vγ2+/Vδ2+, or Vγ1+/Vδ undetermined (2- 1-) T cells, respectively. The other three patients, without persistent expansion of γδ T cells, had either non-deforming and non-erosive oligo- or polyarthritis with a balanced distribution of several Vδ and Vγ genes, or severe erosive RF+ arthritis with deficiency of all but Vγ1+/Vδ1+ T cells. Conclusions: γδ T cell lymphoproliferations in chronic neutropenia and arthritis use different Vγ and Vδ gene families, often forming T cell receptor (TCR) structures that are infrequent in normal adult PB. Arthritis with Vγ1+/Vδ2+, Vγ2+/Vδ2+, or Vγ1+/Vδ2-/Vδ1- γδ T cells in the PB is non-deforming and non-erosive, suggesting a protective effect of these cells, as opposed to a more pathogenic contribution of Vγ1+/Vδ1+ cells.
机译：背景：在关节炎和中性粒细胞减少症患者的外周血（PB）中已证实，γδT细胞亚群的异常分布是关节炎滑膜中炎性浸润的组成部分。目的：评估关节炎和中性粒细胞减少症患者的临床表现是否与PB中主要的特定γδT细胞亚群有关。方法：对连续6例慢性中性粒细胞减少和关节炎患者的PB淋巴细胞进行流式细胞术。通过聚合酶链反应分析可变的（V）γ和δ基因家族。对cDNA进行T细胞受体（TCR）基因的直接自动测序。结果：3例患者患有非变形和非侵蚀性类风湿因子（RF） + 多关节类风湿关节炎，RF + 少关节关节炎或RF -持续扩张Vγ1 + /Vδ2 + ，Vγ2 + /Vδ2 + 的非变形性少关节型银屑病关节炎或Vγ1 + /Vδ未确定的（2-1-1） T细胞。其他三例患者没有持续的γδT细胞扩增，出现了非变形和非侵蚀性寡关节炎或多关节炎，其中多个Vδ和Vγ基因分布均衡，或者患有严重的侵蚀性RF + 关节炎除Vγ1 + /Vδ1 + T细胞外，其余均缺乏。结论：慢性中性粒细胞减少和关节炎中的γδT细胞淋巴组织化使用不同的Vγ和Vδ基因家族，通常形成正常成人PB中很少见的T细胞受体（TCR）结构。 Vγ1 + /Vδ2 + ，Vγ2 + /Vδ2 + 或Vγ1 + /Vδ2- /Vδ1-γδT细胞是无变形和无侵蚀性的，表明这些细胞具有保护作用，而不是更多。 Vγ1 + /Vδ1 + 细胞的致病作用

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