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Serological Investigations of Flavivirus Prevalence in Khammouane Province Lao Peoples Democratic Republic 2007–2008

机译:老挝人民民主共和国卡莫纳省黄病毒流行率的血清学调查2007-2008年

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摘要

A large-scale cross-sectional seroprevalence study of dengue (DEN) and Japanese encephalitis (JE) was conducted in Khammouane province, Lao PDR, as part of the initial baseline health impact assessment of the Nam Theun 2 hydroelectric dam construction project. Health surveys were performed between May 2007 and February 2008 with serum samples collected from healthy individuals involved in the resettlement program of 16 villages (total surveyed population 4,369). Hemagglutination inhibition assay using flavivirus antigens (DENV1, DENV3, and JEV) performed on 1,708 plasma specimens revealed 30.4% (519) cross-reactive positives, and 10% (172) and 1.3% (22) positives to JEV or DENV, respectively. Entomological surveys conducted during the rainy season of 2008 indicated the presence of competent flavivirus vectors (Culex vishnui group and Aedes albopictus), although Aedes aegypti was not found. Continued surveillance and investigation is warranted to assess the clinical disease burden of flaviviruses in this area that is undergoing rapid ecological and demographic change.
机译:作为南屯2号水电大坝建设项目初始基线健康影响评估的一部分,在老挝人民民主共和国进行了大规模的登革热(DEN)和日本脑炎(JE)横断面血清流行病学研究。在2007年5月至2008年2月之间进行了健康调查,从参与16个村庄的安置计划的健康个体收集的血清样本(总调查人口4,369)。使用黄病毒抗原(DENV1,DENV3和JEV)对1708个血浆样本进行的血凝抑制试验显示,JEV或DENV的交叉反应阳性率为30.4%(519),阳性率为10%(172)和1.3%(22)。尽管未发现埃及伊蚊,但在2008年雨季进行的昆虫学调查表明存在有效的黄病毒载体(库蚊vishnui组和白纹伊蚊)。有必要继续进行监视和调查,以评估该地区正在迅速发生生态和人口变化的黄病毒的临床疾病负担。

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