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首页> 美国卫生研究院文献>American Journal of Translational Research >Analysis the prognostic values of solute carrier (SLC) family 39 genes in gastric cancer
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Analysis the prognostic values of solute carrier (SLC) family 39 genes in gastric cancer

机译：溶质载体（SLC）家族39基因在胃癌中的预后价值分析

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Background: Gastric cancer (GC) is one of the most common diagnosed cancer with poor prognosis. Solute carrier (SLC) family 39 genes encode membrane transport proteins, which control the influx of zinc and may play important roles in human disease including cancer. However, the prognostic value of individual SLC family 39 gene in gastric cancer patients remain unclear. Methods: Genetic alteration frequency and mRNA expression level of SLC family 39 genes in GC were first assessed by using many online databases including cBioportal for Cancer Genomics, Oncomine, UCSC Xena browser and Ualcan database. The prognostic value of individual SLC family 39 gene in GC patients were further investigated via Kaplan-Meier plotter. Results: The analytic results of genetic alteration frequency showed that mRNA deregulation was one of the most important single factors for alteration in different kinds of gastric cancer. Compared with normal gastric tissues, 14 SLC family 39 genes were all significantly upregulated in GC tissue in Ualcan database, and SLC39A4, SLC39A5, SLC39A6, SLC39A10 mRNA expression were also higher in Oncomine database. The survival analysis indicated that most members of SLC family 39 genes were closely related with prognosis of GC patients, SLC39A7, SLC39A11, SLC39A14 were significantly associated with favorable overall survival (OS), the rest of SLC family 39 genes were importantly correlated with unfavorable OS except SLC39A10. Conclusion: Our analysis identified that 14 SLC family 39 genes are potential prognostic biomarkers of GC patients, and may offer effective and new strategies for GC therapy.
机译：背景：胃癌（GC）是最常见的预后不良的癌症之一。溶质载体（SLC）家族39个基因编码膜转运蛋白，该蛋白控制锌的流入，并可能在包括癌症在内的人类疾病中发挥重要作用。然而，单个SLC家族39基因在胃癌患者中的预后价值仍不清楚。方法：首先使用许多在线数据库，包括癌症基因组学的cBioportal，Oncomine，UCSC Xena浏览器和Ualcan数据库，评估GC中SLC家族39个基因的遗传改变频率和mRNA表达水平。通过Kaplan-Meier绘图仪进一步研究了单个SLC家族39基因在GC患者中的预后价值。结果：遗传改变频率的分析结果表明，mRNA失调是不同类型胃癌发生改变的最重要的单一因素之一。与正常胃组织相比，Ualcan数据库中的GC组织中有14个SLC家族39基因均显着上调，Oncomine数据库中SLC39A4，SLC39A5，SLC39A6，SLC39A10 mRNA表达也较高。生存分析表明，SLC家族39个基因的大多数成员与GC患者的预后密切相关，SLC39A7，SLC39A11，SLC39A14与总体生存期（OS）显着相关，其余SLC 39家族基因与不良OS密切相关。除了SLC39A10。结论：我们的分析确定了14个SLC家族39个基因是GC患者的潜在预后生物标志物，并可能为GC治疗提供有效和新的策略。

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