Conclusions of segregation analysis for family data generated under two-locus models.

机译：在两地点模式下生成的家庭数据进行隔离分析的结论。

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Susceptibility to a disease may involve the interactive effect of two genes. What conclusions will be drawn by segregation analysis in such a case? To answer this question, we considered a set of two-locus models and the corresponding exact distribution for 300 families. We investigated the conclusions and parameter estimations obtained for this sample, by comparing the likelihood expectations of the unified model and of more restricted models. In many cases, segregation analysis leads to the conclusion of a major gene effect, with or without a polygenic component--usually without a polygenic component in multiplicative models (i.e., where two genes have a multiplicative effect) and with such a component in nonmultiplicative models. For all the models considered, existence of a major gene effect is supported by transmission probability tests; there is evidence for transmission and agreement with the hypothesis of Mendelian transmission. Accordingly, there is no means of detecting that the effect of a major gene, with or without a polygenic component, does not correspond to the correct model. In addition, the parameter estimates for the major gene do not correspond to the characteristics of either of the two genes of the true model. This may substantially affect further linkage analysis.

机译：对疾病的易感性可能涉及两个基因的相互作用。在这种情况下，通过隔离分析将得出什么结论？为了回答这个问题，我们考虑了一套两地点模型和300个家庭的相应确切分布。通过比较统一模型和更严格模型的似然性期望，我们调查了该样本的结论和参数估计。在许多情况下，隔离分析可得出具有或不具有多基因成分的主要基因效应的结论-通常在乘法模型中（即两个基因具有乘法效应的情况下）没有多基因成分，而在非乘法模型中具有这样的成分楷模。对于所有考虑的模型，主要的基因效应的存在都通过传播概率测试来支持；有证据表明传播与孟德尔传播假设一致。因此，没有办法检测具有或不具有多基因成分的主要基因的作用与正确的模型不符。此外，主要基因的参数估计值与真实模型的两个基因中的任何一个都不对应。这可能会严重影响进一步的连锁分析。

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期刊名称 American Journal of Human Genetics
作者
M H Dizier; C Bonaïti-Pellié; F Clerget-Darpoux;
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年(卷),期 1993(53),6
年度 1993
页码 1338–1346
总页数 9
原文格式 PDF
正文语种
中图分类遗传学;
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专利

1. Monte Carlo methods for linkage analysis of two-locus disease models. [J] . Lin S Annals of Human Genetics . 2000,第Pta6期

机译：蒙特卡洛方法用于两基因座疾病模型的连锁分析。
2. SNP Haplotypes in the Angiotensin I-Converting Enzyme (ACE) Gene: Analysis of Nigerian Family Data Using Gamete Competition Models. [J] . McKenzie CA, Sinsheimer JS, Adeyemo AA, Annals of Human Genetics . 2005,第Pta2期

机译：血管紧张素I转换酶（ACE）基因中的SNP单倍型：使用配子竞争模型对尼日利亚家庭数据的分析。
3. Disequilibrium in two-locus mutation-selection balance models. [J] . A Hastings Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 1988,第3期

机译：两基因座突变选择平衡模型中的不平衡。
4. Parametric families of reduced finite element models. Theory and applications [C] . Etienne Balm International Modal Analysis Conference . 2004

机译：减少有限元模型的参数系列。理论与应用
5. Can guided inquiry based labs improve performance in data analysis and conclusion synthesis in sixth grade life science? [D] . Moore, Melonie Ann. 2009

机译：指导性基于查询的实验室能否提高六年级生命科学中数据分析和结论综合的性能？
6. Conclusion of LOD-score analysis for family data generated under two-locus models. [O] . M. H. Dizier, M. C. Babron, F. Clerget-Darpoux 1996

机译：对在两个场所模型下生成的家庭数据进行LOD得分分析的结论。
7. Decision-making is the process of analyzing information about a problem situation and comparing it to a specific conclusion in order to solve a specific problematic (Yıkılmaz, 2001; Miller and Byrnes, 2001). Decision-making styles are a mechanism that is influenced by the internal and external conditions that determine the direction of the decisions of the individual, the content of the decision-making process, and the outcome of the decision-making process (Payne, Bettman and Johson, 1993; Bavol’ár and Orosová, 2015). ACT is a contemporary member of the Cognitive Behavioral Therapy family. ACT (Acceptance and commitment therapy) has both similar and different directions with Behavioral Therapies and Cognitive Therapies (Herbet and Forman, 2011; Hayes, 2004). KKT responds to classical behavioral treatments using both existential and cognitive approaches in the analysis of behavior. KKT is a science wing that tries to solve human problems with a wider perspective aimed at solving problematic human behaviors (Plumb, Stewart, Dahl and Lundgren, 2009). It is seen that there is very little research about the new approach of ACT approach when the aiming country of our country is screened and it is thought that our country will contribute to the field of psychological counseling with the work done. In the scope of the research, experimental and control groups and preliminary test, post-test and follow-up measurements of 2x3 experimental design were used. The study's study group consists of a total of 24 (12 experimental and 12 control groups) university students studying in different departments and levels, continuing their education in the academic year of 2015-2016 in Ağrı province and İbrahim Chechen University in 2015-2016 academic year. The average age of participants in the experiment and control group is 20. There were 12 participants in the experimental group, 7 female and 5 male, and 12 participants, 7 female and 5 male in the control group. Personal Information Form and Decision Making Style Scale prepared by the researcher were used in the research. In order to decide on the tests to be used in the course of analyzing the data, the scores of the participant's Decision Styles Scale pre-test, which are placed primarily in the experimental and control groups, it was analyzed whether the basic expectations of parametric tests were answered. As a result of the analysis made, the scores, skewness and kurtosis coefficients obtained from the Decision Making Styles Scale were given to the experimental and control groups. It was determined that the distribution was normal in the result of Shapiro-Wilk test, in which the skewness and kurtosis coefficients of each sub-scale were ranked between -1 and +1. Participants in the experimental and control groups; homogeneity test results for decision-style pre-test measurements indicate that the data are homogeneous. According to the results of the Mauchly Globalness Test, it has been determined that working supports the hypothesis. It was determined that there was no significant difference between the pre-test scores obtained from dependent decision-making style of experiment and control groups, but the test group showed lower mean scores at the significant level within the scores of post-test and follow-up tests. Therefore, it can be said that the ACT-oriented psychoeducation program applied to the experimental group reduces the dependent decision-making style scores from the decision style sub-dimensions and the psychoeducation program has a lasting effect. It was determined that there was no significant difference between pre-test, post-test and follow-up scores obtained from the Spontaneous-Instant Decision Style of experiment and control groups. Thus, it can be said that this situation does not cause a significant difference in the Spontaneous-Decision-Making Style scores from the decision style sub-dimensions of the ACT-oriented psychoeducation program applied to the experimental group. The ACT -oriented psychoeducation program had a decline in the intuitive decision-making styles of the individuals, but this decrease did not create significant differences. Thus, it can be said that this situation does not make a meaningful difference in the intuitive decision style scores from the decision style sub-dimensions of the KKT oriented psychoeducation program applied to the experimental group. The pre-test scores obtained from the rational decision-making style of the experimental and control groups showed that there was a difference between the post-test and the follow-up scores, but this difference was not significant. As a result of the analysis, it was determined that the test group had higher levels of rational decision style than the pre - test scores in the post test and follow - up scores, whereas the post test and follow - up test scores in the control group rational decision style showed a decrease compared to the pre - test scores. the pre - test scores. Decision-making Styles Scale Avoidant Decision Making As a result of the analysis of the mean scores of the subscale scores of pre-test, post-test and follow-up measures, the group effect was found to be insignificant. It was determined that the experimental and control groups differed significantly from the pre-test scores obtained from the avoidant decision-making style but did not show any significant change within the scores of the post-test and follow-up tests. [O] . mustafa ercengiz, ali haydar şar 2018

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8. Generating Weather Data for Linear Weapons Allocation Models. [R] . Blowers, J. V. 1975

机译：生成线性武器分配模型的天气数据。

Conclusions of segregation analysis for family data generated under two-locus models.

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