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首页> 美国卫生研究院文献>American Journal of Human Genetics >In Swedish families with hereditary prostate cancer linkage to the HPC1 locus on chromosome 1q24-25 is restricted to families with early-onset prostate cancer.
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In Swedish families with hereditary prostate cancer linkage to the HPC1 locus on chromosome 1q24-25 is restricted to families with early-onset prostate cancer.

机译：在患有遗传性前列腺癌的瑞典家庭中与染色体1q24-25上的HPC1基因座的连锁仅限于患有早发型前列腺癌的家庭。

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摘要

Prostate cancer clusters in some families, and an estimated 5%-10% of all cases are estimated to result from inheritance of prostate cancer-susceptibility genes. We previously reported evidence of linkage to the 1q24-25 region (HPC1) in 91 North American and Swedish families each with multiple cases of prostate cancer (Smith et al. 1996). In the present report we analyze 40 (12 original and 28 newly identified) Swedish families with hereditary prostate cancer (HPC) that, on the basis of 40 markers spanning a 25-cM interval within 1q24-25, have evidence of linkage. In the complete set of families, a maximum two-point LOD score of 1.10 was observed at D1S413 (at a recombination fraction [theta] of.1), with a maximum NPL (nonparametric linkage) Z score of 1.64 at D1S202 (P=.05). The evidence of linkage to this region originated almost exclusively from the subset of 12 early-onset (age <65 years) families, which yielded a maximum LOD score of 2.38 at D1S413 (straight theta=0) and an NPL Z score of 1.95 at D1S422 (P=.03). Estimates from heterogeneity tests suggest that, within Sweden, as many as 50% of early-onset families had evidence of linkage to the HPC1 region. These results are consistent with the hypothesis of linkage to HPC1 in a subset of families with prostate cancer, particularly those with an early age at diagnosis.
机译：前列腺癌在某些家庭中聚集，估计所有病例的5％-10％归因于前列腺癌易感基因的遗传。我们先前报道了在91个北美和瑞典家庭中与1q24-25区域（HPC1）连锁的证据，每个家庭均患有多例前列腺癌（Smith et al。1996）。在本报告中，我们分析了40个（遗传性前列腺癌（HPC））瑞典家庭（12个，新发现的28个），它们基于在1q24-25内跨25-cM间隔的40个标记具有联系的证据。在完整的一组家庭中，在D1S413处观察到最大两点LOD得分为1.10（重组分数θ为.1），在D1S202处观察到最大NPL（非参数连锁）Z得分为1.64（P = .05）。与该区域有联系的证据几乎完全来自12个早发（年龄<65岁）家庭的子集，在D1S413（直线theta = 0）产生的最大LOD得分为2.38，在D1S413产生的NPL Z得分为1.95。 D1S422（P = .03）。异质性测试的估计表明，在瑞典内部，多达50％的早发家庭具有与HPC1区域相关的证据。这些结果与在一部分患有前列腺癌的家庭中，特别是在诊断早期的家庭中，与HPC1连锁的假设相一致。

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