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首页> 美国卫生研究院文献>American Journal of Cancer Research >DWI and DCE-MRI approaches for differentiating reversibly electroporated penumbra from irreversibly electroporated ablation zones in a rabbit liver model
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DWI and DCE-MRI approaches for differentiating reversibly electroporated penumbra from irreversibly electroporated ablation zones in a rabbit liver model

机译：DWI和DCE-MRI方法用于区分兔肝模型中可逆电穿孔半影与不可逆电穿孔消融区

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The purpose of our study was to investigate the hypothesis that DWI-MRI and DCE-MRI cab be used to distinguish between IRE and RE zones of IRE treatment in a rabbit liver model. 6 rabbits underwent baseline and post-procedure MR imaging with DWI and DCE-MRI as well as IRE (10 pulses, 2000 V, 10 µs/pulse, 10 ms between pulses). Rabbits were euthanized immediately after post-procedure MRI to acquire liver tissue for histology. Liver tissues were fixed and then stained with HE and TUNEL. T1w and T2w intensities in different treatment zones were calculated and normalized to paraspinal muscle signal. ADC maps were generated from DWI. AUC, PE, TTP, WIS, Ktrans, Kep, and VE were calculated from DCE-MRI. Apoptosis index was calculated from TUNEL stained tissues. P<0.05 was considered statistically significant. Entire IRE treated region was hyperintense compared with untreated tissues on T1w, with the RE zone having a higher signal intensity. On DWI, IRE treated tissue had decreased ΔADC. The IRE zone has a lower ΔADC than the RE zone within the treated region. On DCE-MRI, IRE zone demonstrated the highest TTP and the lowest PE, WIS, Ktrans, Kep, and VE, followed by the RE zone then the untreated tissue. TUNEL staining of liver tissues showed that the IRE zone had the highest apoptosis index, followed by the RE zone and then untreated tissue. In conclusion, DCE-MRI and DWI parameters allow differentiation between RE and IRE zones in a rabbit liver model.
机译：我们的研究目的是研究以下假设：在兔肝模型中，DWI-MRI和DCE-MRI cab可用于区分IRE和IRE治疗的IRE区。 6只兔子接受了DWI和DCE-MRI以及IRE（10个脉冲，2000 V，10 µs /脉冲，两个脉冲之间10 ms）的基线和术后MR成像。 MRI术后立即对安乐死的兔子取肝组织进行组织学检查。固定肝组织，然后用HE和TUNEL染色。计算不同治疗区域的T1w和T2w强度，并根据椎旁肌信号进行归一化。 ADC图是从DWI生成的。根据DCE-MRI计算AUC，PE，TTP，WIS，Ktrans，Kep和VE。从TUNEL染色的组织计算凋亡指数。 P <0.05被认为具有统计学意义。与T1w上未经处理的组织相比，整个IRE处理的区域都非常紧张，而RE区的信号强度更高。在DWI上，IRE治疗的组织的ΔADC降低。在治疗区域内，IRE区的ΔADC比RE区的ΔADC低。在DCE-MRI上，IRE区的TTP最高，PE，WIS，Ktrans，Kep和VE最低，其次是RE区，然后是未经处理的组织。肝脏组织的TUNEL染色显示，IRE区具有最高的细胞凋亡指数，其次是RE区，然后是未经处理的组织。总之，DCE-MRI和DWI参数可以区分兔肝模型的RE和IRE区。

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