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首页> 美国卫生研究院文献>Aging and Disease >The Drainage of Interstitial Fluid in the Deep Brain is Controlled by the Integrity of Myelination
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The Drainage of Interstitial Fluid in the Deep Brain is Controlled by the Integrity of Myelination

机译：大脑深层组织液的排出受髓鞘完整性的控制

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摘要

In searching for the drainage route of the interstitial fluid (ISF) in the deep brain, we discovered a regionalized ISF drainage system as well as a new function of myelin in regulating the drainage. The traced ISF from the caudate nucleus drained to the ipsilateral cortex along myelin fiber tracts, while in the opposite direction, its movement to the adjacent thalamus was completely impeded by a barrier structure, which was identified as the converged, compact myelin fascicle. The regulating and the barrier effects of myelin were unchanged in AQP4-knockout rats but were impaired as the integrity of boundary structure of drainage system was destroyed in a demyelinated rat model. We thus proposed that the brain homeostasis was maintained within each ISF drainage division locally, rather than across the brain as a whole. A new brain division system and a new pathogenic mechanism of demyelination are therefore proposed.
机译：在寻找深部脑组织间质液（ISF）的引流途径时，我们发现了ISF区域化引流系统以及髓磷脂在调节引流中的新功能。从尾状核追溯的ISF沿髓鞘纤维束流向同侧皮质，而在相反方向上，其向邻近丘脑的运动被屏障结构完全阻碍，该屏障结构被确定为会聚的紧凑的髓鞘束。在AQP4敲除大鼠中，髓磷脂的调节和屏障作用没有改变，但在脱髓鞘的大鼠模型中，由于排水系统边界结构的完整性被破坏，髓磷脂的调节和屏障作用受到损害。因此，我们建议在每个ISF引流区中局部维持大脑稳态，而不是整个大脑。因此，提出了一种新的脑分裂系统和一种新的脱髓鞘致病机制。

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