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首页> 美国卫生研究院文献>Aging (Albany NY) >Associations between the components of metabolic syndrome and the polymorphisms in the peroxisome proliferator-activated receptor gamma (PPAR-γ) the fat mass and obesity-associated (FTO) and the melanocortin-4 receptor (MC4R) genes
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Associations between the components of metabolic syndrome and the polymorphisms in the peroxisome proliferator-activated receptor gamma (PPAR-γ) the fat mass and obesity-associated (FTO) and the melanocortin-4 receptor (MC4R) genes

机译：代谢综合征的成分与过氧化物酶体增殖物激活受体γ（PPAR-γ）脂肪量和肥胖相关（FTO）和黑皮质素4受体（MC4R）基因多态性之间的关联

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Introduction: Metabolic syndrome (MetS) is regarded as a set of abnormalities, increasing the risk of serious functioning disorders. It can develop as a result of genetic predisposition.Aim: The aim of this study was to establish associations between MetS-related abnormalities and the PPAR-γ rs1801282, FTO rs9939609, and MC4R rs17782313 polymorphisms.Material and methods: The study involved 425 women aged 45-60 years. The participants were surveyed and subjected to anthropometric, biochemical and genetic analysis.Results:In the recessive inheritance model for the FTO polymorphism, a statistically significant relationship was demonstrated between the A/A genotype and glycemia. The results obtained in the codominant and overdominant models for the PPAR-y polymorphism showed a tendency to statistical significance (the C/G genotype inclined to hypertriglyceridemia), and were statistically significant in the codominant, dominant, and recessive models (the C/C genotype predisposed to increased blood pressure).Conclusions: 1. MetS-related abnormalities can be genetically determined, however only some of these relationships can be demonstrated due to the categorical division of symptoms according to the IDF criteria from 2009. 2. The A/A genotype of the FTO rs9939609 polymorphism increases the risk of hyperglycemia, and the C/C genotype of the PPAR-γ rs1801282 variant entails elevated blood pressure in 45-60-year-old women.
机译：简介：代谢综合症（MetS）被视为一组异常，增加了发生严重功能障碍的风险。目的：本研究旨在建立与MetS相关的异常与PPAR-γrs1801282，FTO rs9939609和MC4R rs17782313多态性之间的关联。材料与方法：该研究涉及425名女性。年龄45-60岁。结果：在FTO多态性的隐性遗传模型中，A / A基因型与血糖之间存在统计学上的显着关系。在PPAR-y多态性的显性和显性模型中获得的结果显示出具有统计学显着性的趋势（倾向于高甘油三酯血症的C / G基因型），并且在显性，显性和隐性模型中具有统计学意义（C / C结论：1.可以通过遗传学方法确定与MetS相关的异常，但是由于根据IDF从2009年开始的症状分类，这些证据中只有一部分可以得到证实。2. A / FTO rs9939609多态性的基因型增加了高血糖的风险，PPAR-γrs1801282变体的C / C基因型导致45-60岁女性的血压升高。

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