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首页> 美国卫生研究院文献>International Journal of Clinical and Experimental Medicine >Serum and biliary MMP-9 and TIMP-1 concentrations in the diagnosis of cholangiocarcinoma
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Serum and biliary MMP-9 and TIMP-1 concentrations in the diagnosis of cholangiocarcinoma

机译：血清和胆汁MMP-9和TIMP-1浓度在胆管癌的诊断中

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Aim: Cholangiocarcinoma is generally detected late in the course of disease, and current diagnostic techniques often fail to differentiate benign from malignant disease. Ongoing biomarker studies for early diagnosis of cholangiocarcinoma are still continues. By this study, we analyzed the roles of serum and biliary MMP-9 and TIMP-1 concentrations in the diagnosis of cholangiocarcinoma. Materials and methods: The 113 patients (55 males, 58 females) were included; 33 diagnosed with cholangiocarcinoma (malignant group) and 80 diagnosed with choledocholithiasis (benign group). MMP-9 and TIMP-1 concentrations were analyzed in serum and bile and compared in the malignant and benign groups. Results were evaluated statistically. Results: Biliary MMP-9 concentrations were significantly higher (576 ± 209 vs. 403 ± 140 ng/ml, p < 0.01) and biliary TIMP-1 concentrations were significantly lower (22.4 ± 4.9 vs. 29.4 ± 6.1 ng/ml, p < 0.01) in the malignant than in the benign group. In contrast, serum MMP-9 and TIMP-1 concentrations were similar in the two groups. Receiver operating curve analysis revealed that the areas under the curve of bile MMP-9 and TIMP-1 were significantly higher than 0.5 (p < 0.001). The sensitivity, specificity, positive and negative predictive values, positive and negative likelihood ratios and accuracy were 0.94, 0.32, 0.36, 0.93, 1.40, 0.19 and 0.5 for biliary MMP-9, respectively, and 0.97, 0.36, 0.39, 0.97, 1.5, 0.08 and 0.54 for biliary TIMP-1, respectively. Conclusion: Serum and biliary MMP-9 and TIMP-1 tests do not appear to be useful in the diagnosis of cholangiocarcinoma.
机译：目的：胆管癌通常在疾病晚期被发现，目前的诊断技术通常无法区分良性与恶性疾病。早期诊断胆管癌的生物标志物仍在继续。通过这项研究，我们分析了血清和胆汁MMP-9和TIMP-1浓度在胆管癌诊断中的作用。资料与方法：纳入113例患者（男55例，女58例）。 33例诊断为胆管癌（恶性组），80例诊断为胆管结石症（良性组）。分析血清和胆汁中MMP-9和TIMP-1的浓度，并在恶性和良性组中进行比较。对结果进行统计学评估。结果：胆道MMP-9浓度显着升高（576±209 vs. 403±140 ng / ml，p <0.01），胆汁TIMP-1浓度显着降低（22.4±4.9 vs. 29.4±6.1 ng / ml，p <0.01）恶性程度高于良性组。相反，两组的血清MMP-9和TIMP-1浓度相似。接收器工作曲线分析表明，胆汁MMP-9和TIMP-1曲线下的面积显着高于0.5（p <0.001）。胆道MMP-9的敏感性，特异性，阳性和阴性预测值，阳性和阴性似然比和准确性分别为0.94、0.32、0.36、0.93、1.40、0.19和0.5，以及0.97、0.36、0.39、0.97、1.5 ，对于胆管TIMP-1分别为0.08和0.54。结论：血清和胆汁MMP-9和TIMP-1检测似乎对胆管癌的诊断没有帮助。

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