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首页> 外文期刊>Clinical chemistry and laboratory medicine: CCLM >Serum MMP-9 and TIMP-1 concentrations and MMP-9 activity during surgery-induced inflammation in humans.
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Serum MMP-9 and TIMP-1 concentrations and MMP-9 activity during surgery-induced inflammation in humans.

机译：手术引起的人类炎症期间的血清MMP-9和TIMP-1浓度以及MMP-9活性。

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摘要

Matrix metalloproteinase 9 (MMP-9) and the endogenous inhibitor to MMP-9, tissue inhibitor of metalloproteinase 1 (TIMP-1), have important roles in tissue remodelling and are implicated in a number of diseases related to inflammation. The time course in activation and formation of MMPs and TIMPs during an inflammatory reaction is not fully known. This study investigates MMP-9 and TIMP-1 concentrations and MMP-9 activity at different time points after major surgery when a state of noticeable inflammation is expected.Serum MMP-9 and TIMP-1 concentrations and MMP-9 activity were analysed preoperatively and 4 and 30 days postoperatively in patients undergoing elective surgery (coronary artery bypass n=21; orthopaedic surgery, n=29).Serum TIMP-1 and MMP-9 activity increased significantly 4 days after surgery (p<0.05 and p<0.01, respectively) and decreased again 30 days after surgery (p<0.01, respectively, compared to 4 days after surgery). Serum MMP-9 increased significantly 4 days after surgery (p<0.05) and was still high 30 days after surgery (p<0.01 compared to before surgery). The calculated MMP-9/TIMP-1 ratio was increased 30 days after surgery compared to before surgery (p<0.01).The inflammatory state induced by elective surgery is associated with increased TIMP-1 response and MMP-9 activity in serum within a few days which may be of importance for the postoperative heeling process. The further increase in MMP-9 concentrations at day 30 postoperative did not result in increased MMP-9 activity. Serum MMP-9 concentrations or the calculated MMP-9/TIMP-1 ratio do not entirely represent MMP-9 activity during surgery-induced inflammation.
机译：基质金属蛋白酶9（MMP-9）和MMP-9的内源性抑制剂，金属蛋白酶1的组织抑制剂（TIMP-1），在组织重塑中具有重要作用，并涉及许多与炎症相关的疾病。炎症反应过程中MMP和TIMP活化和形成的时间过程尚不完全清楚。本研究调查了预期出现明显炎症状态的大手术后不同时间点的MMP-9和TIMP-1浓度以及MMP-9活性。术前分析了血清MMP-9和TIMP-1浓度以及MMP-9活性接受择期手术的患者术后4天和30天（冠状动脉搭桥术n = 21;骨科手术，n = 29）。术后4天血清TIMP-1和MMP-9活性显着增加（p <0.05和p <0.01，并分别在术后30天降低（分别为p <0.01，与术后4天相比）。术后4天血清MMP-9显着增加（p <0.05），并且在术后30天仍较高（与手术前相比p <0.01）。与手术前相比，手术后30天的MMP-9 / TIMP-1比值增加了（p <0.01）。择期手术诱发的炎症状态与TIMP-1反应的增强和血清中MMP-9活性的增加有关。几天可能对术后足跟过程很重要。术后30天MMP-9浓度的进一步增加并未导致MMP-9活性增加。血清MMP-9浓度或计算得出的MMP-9 / TIMP-1比值并不完全代表手术诱发的炎症过程中的MMP-9活性。

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