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首页> 美国卫生研究院文献>International Journal of Clinical and Experimental Medicine >Oxidative stress parameters and their correlation with clinical metabolic and polysomnographic parameters in severe obstructive sleep apnea syndrome
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Oxidative stress parameters and their correlation with clinical metabolic and polysomnographic parameters in severe obstructive sleep apnea syndrome

机译：严重阻塞性睡眠呼吸暂停综合征的氧化应激参数及其与临床代谢和多导睡眠图参数的相关性

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The aim of the present study was to assess the levels of oxidative stress markers, catalase (CAT), glutathione peroxidase (GPX) and malondialdehyde (MDA) in severe OSAS and to investigate any correlation between oxidative stress markers and clinical, metabolic and polysomnographic parameters. A total of 30 patients with severe OSAS and 30 healthy controls were included in this cross-sectional, clinical study. Demographic data, polysomnographic, biochemical and clinical indices as well as serum levels of CAT, MDA and GPX were measured and compared in OSAS and control groups. Furthermore, OSAS patients with and without pulmonary hypertension (PHT) were evaluated in terms of levels of CAT, MDA and GPX. Patients with severe OSAS exhibited significantly lower serum levels of CAT (P<0.001) and GPX (P<0.001). Serum MDA levels were remarkably higher in OSAS group (P<0.001). Correlation analysis revealed that levels of CAT and GPX were correlated with apnea-hypopnea index and there was a correlation between serum levels of MDA and CRP. Severe OSAS patients with and without PHT did not reveal any differences for CAT (P=0.789), MDA (P=0.805) and GPX levels (P=0.281). Our results have shown that oxidative stress markers significantly changed in patients with severe OSAS. This information is noteworthy because documentation of the role of oxidative stress in OSAS may have important implications regarding diagnosis, monitoring, treatment and prognosis.
机译：本研究的目的是评估严重OSAS中氧化应激指标，过氧化氢酶（CAT），谷胱甘肽过氧化物酶（GPX）和丙二醛（MDA）的水平，并研究氧化应激指标与临床，代谢和多导睡眠图参数之间的任何相关性。这项横断面临床研究共纳入30例严重OSAS患者和30例健康对照。在OSAS组和对照组中测量并比较了人口统计学数据，多导睡眠图，生化和临床指标以及CAT，MDA和GPX的血清水平。此外，根据CAT，MDA和GPX的水平评估了患有和不患有肺动脉高压（PHT）的OSAS患者。患有严重OSAS的患者的血清CAT（P <0.001）和GPX（P <0.001）明显降低。 OSAS组的血清MDA水平显着升高（P <0.001）。相关分析表明，CAT和GPX的水平与呼吸暂停低通气指数相关，而MDA和CRP的血清水平之间存在相关性。患有和不患有PHT的严重OSAS患者没有发现CAT（P = 0.789），MDA（P = 0.805）和GPX水平（P = 0.281）有任何差异。我们的结果表明，严重OSAS患者的氧化应激标志物发生了显着变化。该信息值得注意，因为有关氧化应激在OSAS中的作用的文献可能对诊断，监测，治疗和预后具有重要意义。

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