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首页> 美国卫生研究院文献>International Journal of Molecular Sciences >Social Learning of Acquiring Novel Feeding Habit in Mandarin Fish (Siniperca chuatsi)
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Social Learning of Acquiring Novel Feeding Habit in Mandarin Fish (Siniperca chuatsi)

机译：习俗性鱼类习性习得的社会学习

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Social learning plays important roles in gaining new foraging skills and food preferences. However, the potential role and molecular mechanism of social learning in acquiring new feeding habits is less clear in fish. In the present study, we examined the success rate of feeding habit domestication from live prey fish to dead prey fish, as well as the food intake of dead prey fish in mandarin fish with or without feeders of dead prey fish as demonstrators. Here, we found that mandarin fish can learn from each other how to solve novel foraging tasks, feeding on dead prey fish. In addition, the analysis of gene expressions and signaling pathways of learning through Western blotting and transcriptome sequencing shows that the expression of the c-fos, fra2, zif268, c/ebpd and sytIV genes were significantly increased, and the anorexigenic pomc and leptin a expressions were decreased in fish of the learning group. The phosphorylation levels of protein kinase A (PKA) and Ca2+/calmodulin-dependent protein kinase II (CaMKII) in the learning group were significantly higher than those of the control group, while the phosphorylation level of S6 ribosomal protein (S6) was lower. With the inhibitors of PKA and CaMKII signaling and the chromatin immunoprecipitation (ChIP) assay, we further found that the social learning of new feeding habits in mandarin fish could be attributed to the activation of the CaMKII signaling pathway and then the stimulation of the expression of the c-fos gene, which might be an important transcriptional factor to inhibit the expression of the anorexigenic gene pomc, resulting in the food intake of dead prey fish in mandarin fish. Altogether, our results support the hypothesis that social learning could facilitate the acquisition of novel feeding habits in fish, and it considerably increases the rate of subsequent individual food intake and domestication through the interaction between the learning gene c-fos and the appetite control gene pomc.
机译：社会学习在获得新的觅食技能和食物偏好方面起着重要作用。然而，在鱼类中，社会学习在养成新的喂养习惯方面的潜在作用和分子机制尚不清楚。在本研究中，我们研究了从活的猎物鱼到死的猎物的养成习惯驯化的成功率，以及在有或没有死者的饲养者作为示范者的情况下，man鱼中的死猎物的食物摄入量。在这里，我们发现man鱼可以互相学习如何解决新的觅食任务，以死猎物鱼为食。此外，通过蛋白质印迹和转录组测序对基因表达和学习信号通路的分析表明，c-fos，fra2，zif268，c / ebpd和sytIV基因的表达显着增加，而致厌食性pomc和瘦素a在学习组的鱼中表达降低。学习组中蛋白激酶A（PKA）和Ca 2 + /钙调蛋白依赖性蛋白激酶II（CaMKII）的磷酸化水平显着高于对照组，而学习组的磷酸化水平明显高于对照组。 S6核糖体蛋白（S6）较低。通过PKA和CaMKII信号的抑制剂以及染色质免疫沉淀（ChIP）分析，我们进一步发现，对new鱼新的摄食习性的社会学习可以归因于CaMKII信号通路的激活，然后刺激了CaMKII信号通路的表达。 c-fos基因可能是抑制厌食基因pomc表达的重要转录因子，导致resulting鱼中死猎物的食物摄入。总之，我们的结果支持以下假设：社会学习可以促进鱼类养成新的摄食习惯，并且通过学习基因c-fos和食欲控制基因pomc的相互作用，可以大大提高随后个体食物的摄取和驯化率。 。

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