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首页> 美国卫生研究院文献>Advances in Wound Care >Chemokines in Wound Healing and as Potential Therapeutic Targets for Reducing Cutaneous Scarring
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Chemokines in Wound Healing and as Potential Therapeutic Targets for Reducing Cutaneous Scarring

机译：伤口愈合中的趋化因子和减少皮肤瘢痕形成的潜在治疗靶点

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>Significance: Cutaneous scarring is an almost inevitable end point of adult human wound healing. It is associated with significant morbidity, both physical and psychological. Pathological scarring, including hypertrophic and keloid scars, can be particularly debilitating. Manipulation of the chemokine system may lead to effective therapies for problematic lesions.>Recent Advances: Rapid advancement in the understanding of chemokines and their receptors has led to exciting developments in the world of therapeutics. Modulation of their function has led to clinically effective treatments for conditions as diverse as human immunodeficiency virus and inflammatory bowel disease. Potential methods of targeting chemokines include monoclonal antibodies, small-molecule antagonists, interference with glycosaminoglycan binding and the use of synthetic truncated chemokines. Early work has shown promising results on scar development and appearance when the chemokine system is manipulated.>Critical Issues: Chemokines are implicated in all stages of wound healing leading to the development of a cutaneous scar. An understanding of entirely regenerative wound healing in the developing fetus and how the expression of chemokines and their receptors change during the transition to the adult phenotype is central to addressing pathological scarring in adults.>Future Directions: As our understanding of chemokine/receptor interactions and scar formation evolves it has become apparent that effective therapies will need to mirror the complexities in these diverse biological processes. It is likely that sophisticated treatments that sequentially influence multiple ligand/receptor interactions throughout all stages of wound healing will be required to deliver viable treatment options.
机译：>意义：皮肤瘢痕形成是成人伤口愈合几乎不可避免的终点。它与身体和心理上的高发病率有关。病理性瘢痕，包括肥厚性瘢痕瘤和瘢痕loid瘢痕，可能特别使人虚弱。操纵趋化因子系统可能会导致对有问题的病变进行有效的治疗。>最近的进展：对趋化因子及其受体的理解的迅速发展导致了治疗领域的激动人心的发展。其功能的调节已导致针对人类免疫缺陷病毒和炎性肠病等多种疾病的临床有效治疗。靶向趋化因子的潜在方法包括单克隆抗体，小分子拮抗剂，干扰糖胺聚糖结合以及使用合成的截短型趋化因子。早期的研究表明，当操纵趋化因子系统时，瘢痕的产生和外观具有可喜的结果。>关键问题：趋化因子与伤口愈合的所有阶段有关，导致皮肤瘢痕的发展。了解发育中胎儿的完全再生伤口愈合以及趋化因子及其受体在成年表型转变过程中的表达变化是解决成人病理性瘢痕形成的关键。>未来方向：趋化因子/受体相互作用和疤痕形成的进展，显而易见的是，有效的疗法将需要反映这些不同生物学过程中的复杂性。为了提供可行的治疗选择，可能需要在伤口愈合的所有阶段中依次影响多个配体/受体相互作用的复杂治疗方法。

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