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首页> 美国卫生研究院文献>American Journal of Physiology - Lung Cellular and Molecular Physiology >Bioengineering the Lung: Molecules Materials Matrix Morphology and Mechanics: Coming to terms with tissue engineering and regenerative medicine in the lung
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Bioengineering the Lung: Molecules Materials Matrix Morphology and Mechanics: Coming to terms with tissue engineering and regenerative medicine in the lung

机译：肺生物工程：分子材料基质形态学和力学：涉及肺中的组织工程学和再生医学

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摘要

Lung diseases such as emphysema, interstitial fibrosis, and pulmonary vascular diseases cause significant morbidity and mortality, but despite substantial mechanistic understanding, clinical management options for them are limited, with lung transplantation being implemented at end stages. However, limited donor lung availability, graft rejection, and long-term problems after transplantation are major hurdles to lung transplantation being a panacea. Bioengineering the lung is an exciting and emerging solution that has the ultimate aim of generating lung tissues and organs for transplantation. In this article we capture and review the current state of the art in lung bioengineering, from the multimodal approaches, to creating anatomically appropriate lung scaffolds that can be recellularized to eventually yield functioning, transplant-ready lungs. Strategies for decellularizing mammalian lungs to create scaffolds with native extracellular matrix components vs. de novo generation of scaffolds using biocompatible materials are discussed. Strengths vs. limitations of recellularization using different cell types of various pluripotency such as embryonic, mesenchymal, and induced pluripotent stem cells are highlighted. Current hurdles to guide future research toward achieving the clinical goal of transplantation of a bioengineered lung are discussed.
机译：肺气肿，间质纤维化和肺血管疾病等肺病会导致大量发病和死亡，但尽管对机制有充分的了解，但对它们的临床治疗选择仍然有限，最终阶段要进行肺移植。然而，有限的供体肺可用性，移植排斥和移植后的长期问题是使肺移植成为万能药的主要障碍。肺部生物工程学是一种令人兴奋的新兴解决方案，其最终目的是为移植生成肺组织和器官。在本文中，我们捕获并回顾了肺生物工程领域的最新技术，从多模式方法到创建解剖学上合适的肺支架，这些支架可以重新细胞化以最终产生功能良好的可移植肺。讨论了使用生物相容性材料将哺乳动物的肺脱细胞以创建具有天然细胞外基质成分的支架与从头开始生成支架的策略。强调了使用各种多能性的不同细胞类型（例如胚胎，间充质和诱导性多能干细胞）进行细胞重组的优势与局限性。讨论了当前的障碍，以指导未来的研究以实现生物工程肺移植的临床目标。

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