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首页> 美国卫生研究院文献>American Journal of Physiology - Regulatory Integrative and Comparative Physiology >Nutrient-specific feeding and endocrine effects of jejunal infusions in obese animals
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Nutrient-specific feeding and endocrine effects of jejunal infusions in obese animals

机译：空腹输注对肥胖动物的营养特异性喂养和内分泌作用

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Intestinal nutrient infusions result in variable decreases in food intake and body weight based on the nutrient type and the specific intestinal infusion site. We previously found that intrajejunal infusions of a fatty acid and glucose, but not casein hydrolysate, decreases food intake and body weight in lean chow-fed laboratory rats. To test whether obese, high fat-fed animals would show similar decreases in food intake and body weight in response to intrajejunal infusions of the same nutrients, equal kilocalorie loads of these nutrients (11.4 kcal) or vehicle were infused into the jejunum of obese, high fat-fed male Sprague-Dawley rats over 7 h/day for 5 consecutive days. Food intake was continuously monitored, and body weight was measured daily. After the infusion on the final day, rats were killed and plasma was collected. Similar to lean chow-fed rats, intrajejunal infusions of linoleic acid (LA) and glucose (Glu), but not casein hydrolysate (Cas), suppressed food intake with no compensatory increase in food intake after the infusion period. In contrast to lean chow-fed rats, only the LA, and not the Glu or Cas, produced decreases in body weight in the obese high fat-fed rat. There also were no differences in plasma glucagon-like peptide-1 levels in any of the nutrient infusion groups compared with saline infusion. These results suggest that there is a differential response to the same nutrients in lean vs. obese animals.
机译：肠内营养液的注入会根据营养素类型和特定的肠内输液部位而导致食物摄入量和体重的可变下降。我们以前发现，在空肠内注入脂肪酸和葡萄糖，而不是酪蛋白水解物，可以减少瘦饲料喂养的实验大鼠的食物摄入量和体重。为了测试肥胖，高脂喂养的动物是否会因向空肠内注入相同的营养素而显示出食物摄入量和体重的类似下降，将这些营养素的等量卡路里（11.4大卡）或赋形剂注入肥胖的空肠中，高脂喂养的雄性Sprague-Dawley大鼠连续7天/天超过7小时/天。持续监测食物摄入，每天测量体重。在最后一天输注后，杀死大鼠并收集血浆。与瘦饲料喂养的大鼠类似，在空肠内注入亚油酸（LA）和葡萄糖（Glu），但不抑制酪蛋白水解物（Cas），可以抑制食物摄入，但输注后食物摄入没有补偿性增加。与瘦饲料喂养的大鼠相反，肥胖的高脂肪喂养的大鼠只有LA而不是Glu或Cas导致体重下降。与盐水输注相比，任何营养输注组的血浆胰高血糖素样肽-1水平也没有差异。这些结果表明，瘦和肥胖动物对相同营养物质的反应不同。

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