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首页> 美国卫生研究院文献>The American Journal of Clinical Nutrition >No improvement in suboptimal vitamin A status with a randomized double-blind placebo-controlled trial of vitamin A supplementation in children with sickle cell disease
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No improvement in suboptimal vitamin A status with a randomized double-blind placebo-controlled trial of vitamin A supplementation in children with sickle cell disease

机译：镰状细胞病儿童补充补充维生素A的随机双盲安慰剂对照试验未达最佳维生素A状况无改善

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>Background: Suboptimal vitamin A status is prevalent in children with type SS sickle cell disease (SCD-SS) and is associated with hospitalizations and poor growth and hematologic status. The supplemental vitamin A dose that optimizes suboptimal vitamin A status in this population is unknown.>Objective: The efficacy of Recommended Dietary Allowance (RDA) doses (based on age and sex) of vitamin A (300, 400, or 600 μg retinyl palmitate/d) or vitamin A + zinc (10 or 20 mg zinc sulfate/d) compared with placebo to optimize vitamin A status was assessed in children aged 2.0–12.9 y with SCD-SS and a suboptimal baseline serum retinol concentration (<30 μg/dL).>Design: In this randomized, double-blind, placebo-controlled trial, vitamin A status (serum retinol, prealbumin, retinol-binding protein, and relative-dose-response test) and disease-related illness events were assessed.>Results: Twelve months of vitamin A supplementation at the doses recommended for healthy US children (based on age and sex) failed to improve serum retinol values in either group (vitamin A: n = 23; vitamin A + zinc: n = 18) compared with placebo (n = 21). By 12 mo, the increase (±SD) in serum retinol (3.6 ± 2.8 μg/dL) in those taking 600 μg vitamin A/d was significantly different from the decrease (±SD; −2.8 ± 2.4 μg/dL) in those taking 300 μg/d, which possibly suggests a dose-response relation (P < 0.05) with RDA doses.>Conclusions: Compared with placebo, 12 mo of vitamin A supplementation at the RDA for healthy children did not improve serum retinol values in children with SCD-SS, which possibly suggests that higher doses are needed. However, the existence of alternative conclusions emphasizes the need for future research.
机译：>背景：SS型镰状细胞病（SCD-SS）儿童普遍存在维生素A不足的状况，并且与住院，生长不良和血液学状况有关。未知可优化该人群中次优维生素A状况的补充维生素A剂量。>目的：推荐饮食津贴（RDA）剂量（基于年龄和性别）对维生素A的功效（300，400或安慰剂与600 mg棕榈酸视黄酯/ d）或维生素A +锌（10或20 mg硫酸锌/ d）比较，以优化维生素A状况，以2.0–12.9岁的SCD-SS和基线血清欠佳的儿童为对象视黄醇浓度（<30μg/ dL）。>设计：在该随机，双盲，安慰剂对照试验中，维生素A状态（血清视黄醇，前白蛋白，视黄醇结合蛋白和相对剂量） >结果：为健康的美国儿童（基于年龄和性别）推荐的剂量补充维生素A 12个月未能改善血清维生素A的水平。两组（维生素A：n = 23；维生素A +锌：n = 18）相比，安慰剂（n = 21）。到12个月时，服用600μg维生素A / d的人的血清视黄醇的增加（±SD）（3.6±2.8μg/ dL）与那些人的减少值（±SD; -2.8±2.4μg/ dL）有显着差异服用300μg/ d，这可能与RDA剂量呈剂量反应关系（P <0.05）。>结论：与安慰剂相比，健康儿童RDA补充12 mo维生素A没有改善患有SCD-SS的儿童的血清视黄醇值，这可能表明需要更高的剂量。但是，替代结论的存在强调了未来研究的必要性。

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