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首页> 美国卫生研究院文献>Bioanalysis >Integrating ion mobility spectrometry into mass spectrometry-based exposome measurements: what can it add and how far can it go?
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Integrating ion mobility spectrometry into mass spectrometry-based exposome measurements: what can it add and how far can it go?

机译：将离子迁移谱仪集成到基于质谱的暴露测量中：它可以添加什么可以走多远？

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摘要

Measuring the exposome remains a challenge due to the range and number of anthropogenic molecules that are encountered in our daily lives, as well as the complex systemic responses to these exposures. One option for improving the coverage, dynamic range and throughput of measurements is to incorporate ion mobility spectrometry (IMS) into current MS-based analytical methods. The implementation of IMS in exposomics studies will lead to more frequent observations of previously undetected chemicals and metabolites. LC-IMS-MS will provide increased overall measurement dynamic range, resulting in detections of lower abundance molecules. Alternatively, the throughput of IMS-MS alone will provide the opportunity to analyze many thousands of longitudinal samples over lifetimes of exposure, capturing evidence of transitory accumulations of chemicals or metabolites. The volume of data corresponding to these new chemical observations will almost certainly outpace the generation of reference data to enable their confident identification. In this perspective, we briefly review the state-of-the-art in measuring the exposome, and discuss the potential use for IMS-MS and the physico-chemical property of collisional cross section in both exposure assessment and molecular identification.
机译：由于我们日常生活中遇到的人为分子的范围和数量以及对这些暴露的复杂系统反应，因此测量暴露体仍然是一个挑战。改善测量范围，动态范围和通量的一种选择是将离子迁移谱（IMS）纳入当前基于MS的分析方法中。在蛋白质组学研究中实施IMS将导致对以前未发现的化学物质和代谢物的观察更加频繁。 LC-IMS-MS将提供更大的整体测量动态范围，从而可检测出较低丰度的分子。或者，仅IMS-MS的通量将提供机会在暴露的整个生命周期中分析成千上万的纵向样品，从而捕获化学物质或代谢物的短暂积累的证据。与这些新化学观测结果相对应的数据量几乎肯定会超过参考数据的生成，从而能够对其进行可靠的识别。从这个角度出发，我们简要回顾了测量暴露体的最新技术，并讨论了IMS-MS的潜在用途以及碰撞截面的理化性质在暴露评估和分子鉴定中的应用。

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