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Activation of neuronal N-methyl-d-aspartate receptor plays a pivotal role in Japanese encephalitis virus-induced neuronal cell damage

机译：神经元N-甲基-d-天冬氨酸受体的激活在日本脑炎病毒引起的神经元细胞损伤中起关键作用

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摘要

BackgroundOverstimulation of glutamate receptors, especially neuronal N-methyl-d-aspartate receptor (NMDAR), mediates excitatory neurotoxicity in multiple neurodegenerative diseases. However, the role of NMDAR in the regulation of Japanese encephalitis virus (JEV)-mediated neuropathogenesis remains undisclosed. The primary objective of this study was to understand the function of NMDAR to JEV-induced neuronal cell damage and inflammation in the central nervous system.

机译：背景谷氨酸受体特别是神经元N-甲基-d-天冬氨酸受体（NMDAR）的过度刺激介导了多种神经退行性疾病的兴奋性神经毒性。但是，NMDAR在调节日本脑炎病毒（JEV）介导的神经发病机制中的作用尚未公开。这项研究的主要目的是了解NMDAR对JEV诱导的中枢神经系统神经元细胞损伤和炎症的作用。

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期刊名称 Journal of Neuroinflammation
作者
Zheng Chen; Xugang Wang; Usama Ashraf; Bohan Zheng; Jing Ye; Dengyuan Zhou; Hao Zhang; Yunfeng Song; Huanchun Chen; Shuhong Zhao; Shengbo Cao;
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作者单位

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年(卷),期 2018(15),-1
年度 2018
页码 238
总页数 13
原文格式 PDF
正文语种
中图分类神经科学;
关键词
JEV NMDAR Activation MK-801 Neuronal death;

机译：JEV;NMDAR;激活;MK-801;神经元死亡;

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专利

1. Innate immune mechanisms in japanese encephalitis virus infection: Effect on transcription of pattern recognition receptors in mouse neuronal cells and brain tissue [J] . FadnisP.R., RaviV., DesaiA., Viral immunology . 2013,第6期

机译：日本脑炎病毒感染的先天免疫机制：对小鼠神经元细胞和脑组织中模式识别受体转录的影响
2. Promotion of neuronal differentiation through activation of N-methyl-D-aspartate receptors transiently expressed by undifferentiated neural progenitor cells in fetal rat neocortex. [J] . Yoneyama M, Nakamichi N, Fukui M, Journal of Neuroscience Research . 2008,第11期

机译：通过激活未分化的神经祖细胞在胎鼠新皮层中瞬时表达的N-甲基-D-天冬氨酸受体的激活来促进神经元分化。
3. Tumor necrosis factor receptor-associated death domain mediated neuronal death contributes to the glial activation and subsequent neuroinflammation in Japanese encephalitis. [J] . Swarup V, Ghosh J, Das S, Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry . 2008,第7期

机译：肿瘤坏死因子受体相关的死亡域介导的神经元死亡有助于日本脑炎的神经胶质活化和随后的神经炎症。
4. Organization of flaviviral replicase proteins in virus-induced membranes: a role for NS1' in Japanese encephalitis virus RNA synthesis [C] . Vijaya Satchidanandam, Pradeep Devappa Uchil, Priti Kuma Novartis Foundation Symposium on New Treatment Strategies for Dengue and Other Flaviviral Diseases . 2006

机译：病毒诱导的膜中的黄病毒复制酶组织：日本脑炎病毒RNA合成中NS1'的作用
5. The role of N-methyl-D-aspartate receptors in neuronal plasticity of the primary visual cortex. [D] . Roberts, Elizabeth Brown. 2001

机译：N-甲基-D-天冬氨酸受体在初级视觉皮层神经元可塑性中的作用。
6. Innate Immune Mechanisms in Japanese Encephalitis Virus Infection: Effect on Transcription of Pattern Recognition Receptors in Mouse Neuronal Cells and Brain Tissue [O] . Prachi Rahul Fadnis, Vasanthapuram Ravi, Anita Desai, -1

机译：日本脑炎病毒感染的先天免疫机制：对小鼠神经元细胞和脑组织中模式识别受体转录的影响。
7. Faculty Opinions recommendation of Activation of neuronal N-methyl-D-aspartate receptor plays a pivotal role in Japanese encephalitis virus-induced neuronal cell damage. [O] . Arup Banerjee 2019

机译：教师意见，神经元N-甲基-D-天冬氨酸受体激活的推荐在日本脑炎病毒诱导的神经元细胞损伤中起着枢转作用。

Activation of neuronal N-methyl-d-aspartate receptor plays a pivotal role in Japanese encephalitis virus-induced neuronal cell damage

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