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Optimizing Dynamic Interactions between a Cardiac Patch and Inflammatory Host Cells

机译：优化心脏补丁与炎症宿主细胞之间的动态相互作用

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Damaged heart muscle has only a minimal ability for regeneration following myocardial infarction in which cardiomyocytes are lost to ischemia. The most clinically promising approach to regeneration of cardiac muscle currently under investigation is that of injecting cardiogenic repair cells or implanting a preformed tissue-engineered patch. While major advances are being made in the derivation of functional human cardiomyocytes and the development of tissue-engineering modalities for cardiac repair, the host environment into which the repair cells are placed is largely overlooked. Within seconds of myocardial ischemia, hypoxia sets in in the myocardium and the inflammatory response starts, characterized by rapid deployment of circulating cells and the release of paracrine and autocrine signals. Therefore, the inflammatory conditions under which these interactions take place, the design of the scaffold material used, and the maturity of the implanted cells will determine the outcomes of any stem cell-based therapy. We discuss here the interactions between implanted and inflammatory cells of the host, which are critical for the design of effective heart repair therapies.
机译：受损的心肌仅具有最小的再生能力，因为心肌梗塞后心肌细胞因缺血而丢失。目前正在研究的再生心肌的最有临床前途的方法是注射心源性修复细胞或植入预制的组织工程贴剂。尽管在功能性人心肌细胞的衍生和用于心脏修复的组织工程方法的发展方面取得了重大进展，但很大程度上忽略了放置修复细胞的宿主环境。在心肌缺血的几秒钟内，心肌中就会出现缺氧，炎症反应开始，其特征是循环细胞迅速展开，旁分泌和自分泌信号释放。因此，发生这些相互作用的炎性条件，所用支架材料的设计以及所植入细胞的成熟度将决定任何基于干细胞疗法的结果。我们在这里讨论宿主的植入细胞与炎症细胞之间的相互作用，这对于设计有效的心脏修复疗法至关重要。

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