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Differential FGF Ligands and FGF Receptors Expression Pattern in Frontal and Parietal Calvarial Bones

机译：额叶和顶叶颅骨骨骼中的差异FGF配体和FGF受体表达模式

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摘要

The mammalian skull vault consists mainly of 5 flat bones, the paired frontals and parietals, and the unpaired interparietal. All of these bones are formed by intramembranous ossification within a layer of mesenchyme, the skeletogenic membrane, located between the dermal mesenchyme and the meninges surrounding the brain. While the frontal bones are of neural crest in origin, the parietal bones arise from mesoderm. The present study is a characterization of frontal and parietal bones at their molecular level, aiming to highlight distinct differences between the neural crest-derived frontal and mesodermal-derived parietal bone. We performed a detailed comparative gene expression profile of FGF ligands and their receptors known to play crucial role in skeletogenesis. This analysis revealed that a differential expression pattern of the major FGF osteogenic molecules and their receptors exists between the neural crest-derived frontal bone and the paraxial mesoderm-derived parietal bone. Particularly, the expression of ligands such as Fgf-2, Fgf-9 and Fgf-18 was upregulated in frontal bone on embryonic day 17.5, postnatal day 1 and postnatal day 60 mice. Frontal bone also elaborated higher levels of Fgf receptor 1, 2 and 3 transcripts versus parietal bone. Taken together, these data suggest that the frontal bone is a domain with higher FGF-signaling competence than parietal bone.
机译：哺乳动物的头骨穹顶主要由5根扁平骨，成对的额骨和顶骨以及未成对的顶壁间的骨组成。所有这些骨骼都是由位于真皮间充质和大脑周围脑膜之间的间充质层（骨骼形成膜）内的膜内骨化形成的。额骨起源于神经c，而顶骨则起源于中胚层。本研究是额叶和顶骨的分子水平表征，旨在突​​出神经highlight衍生的额叶和中胚层衍生的顶骨之间的明显差异。我们对FGF配体及其受体进行了详细的比较基因表达谱分析，已知它们在骨骼生成中起关键作用。该分析表明，在神经c衍生的额骨和近轴中胚层衍生的顶骨之间存在主要FGF成骨分子及其受体的差异表达模式。特别地，在胚胎第17.5天，出生后第1天和出生后第60天的小鼠的额骨中，诸如Fgf-2，Fgf-9和Fgf-18的配体的表达上调。与顶骨相比，额骨还具有更高水平的Fgf受体1、2和3转录本。综上所述，这些数据表明额骨是一个比顶骨具有更高的FGF信号传导能力的区域。

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