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首页> 美国卫生研究院文献>Experimental and Therapeutic Medicine >Anti-inflammatory effects of water extract from bell pepper (Capsicum annuum L. var. grossum) leaves in vitro
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Anti-inflammatory effects of water extract from bell pepper (Capsicum annuum L. var. grossum) leaves in vitro

机译：青椒水提取物的抗炎作用

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摘要

Fruits and vegetables have been recognized as natural sources of various bioactive compounds. Peppers, one such natural source, are consumed worldwide as spice crops. They additionally have an important role in traditional medicine, as a result of their antioxidant bioactivity via radical scavenging. However, there are no reports regarding the bioactivity of the bell pepper (Capsicum annuum L. var. grossum), a commonly used edible vegetable. The present study aimed to evaluate the anti-inflammatory effect of water extract from bell pepper leaves on mouse spleen cells, and explore the potential mechanism underlying this effect. The extract was prepared through homogenization of bell pepper leaves in deionized water. The sterilized supernatant was added to a mouse spleen cell culture stimulated by concanavalin A. Following 72 h of culture, the levels of inflammatory cytokines in the culture supernatant were measured using a sandwich enzyme-linked immunosorbent assay system, and levels of inflammatory proteins were assessed using western blotting. The bell pepper leaf extract significantly inhibited inflammatory cytokine production, inhibited cell proliferation without producing cytotoxicity, and suppressed the expression of inflammatory proteins. These results suggest that components of the bell pepper leaf extract possess anti-inflammatory activity. The study of the anti-inflammatory mechanism of bell pepper leaf extract has provided useful information on its potential for therapeutic application.
机译：水果和蔬菜已被公认为各种生物活性化合物的天然来源。辣椒是这种天然来源之一，在全球范围内都作为香料作物消费。由于它们通过自由基清除的抗氧化生物活性，它们在传统医学中还具有重要作用。然而，没有关于灯笼椒（辣椒）的生物活性的报道，灯笼椒是一种常用的可食用蔬菜。本研究旨在评估甜椒叶水提取物对小鼠脾细胞的抗炎作用，并探讨其潜在的机制。通过在去离子水中将甜椒叶匀浆来制备提取物。将灭菌的上清液添加至伴刀豆球蛋白A刺激的小鼠脾细胞培养物中。培养72小时后，使用夹心酶联免疫吸附测定系统测量培养上清液中炎性细胞因子的水平，并评估炎性蛋白的水平使用蛋白质印迹法。甜椒叶提取物显着抑制炎性细胞因子的产生，抑制细胞增殖而不产生细胞毒性，并抑制炎性蛋白的表达。这些结果表明甜椒叶提取物的成分具有抗炎活性。甜椒叶提取物的抗炎机制的研究提供了有关其潜在治疗用途的有用信息。

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