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首页> 外文期刊>Experimental and therapeutic medicine >Anti-inflammatory effects of water extract from bell pepper (Capsicum annuum L. var. grossum) leaves in vitro
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Anti-inflammatory effects of water extract from bell pepper (Capsicum annuum L. var. grossum) leaves in vitro

机译：来自甜椒（辣椒Anumum L.Var.Grossum）叶片水提取物的抗炎作用

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摘要

Fruits and vegetables have been recognized as natural sources of various bioactive compounds. Peppers, one such natural source, are consumed worldwide as spice crops. They additionally have an important role in traditional medicine, as a result of their antioxidant bioactivity via radical scavenging. However, there are no reports regarding the bioactivity of the bell pepper (Capsicum annuum L. var. grossum), a commonly used edible vegetable. The present study aimed to evaluate the anti-inflammatory effect of water extract from bell pepper leaves on mouse spleen cells, and explore the potential mechanism underlying this effect. The extract was prepared through homogenization of bell pepper leaves in deionized water. The sterilized supernatant was added to a mouse spleen cell culture stimulated by concanavalin A. Following 72 h of culture, the levels of inflammatory cytokines in the culture supernatant were measured using a sandwich enzyme-linked immunosorbent assay system, and levels of inflammatory proteins were assessed using western blotting. The bell pepper leaf extract significantly inhibited inflammatory cytokine production, inhibited cell proliferation without producing cytotoxicity, and suppressed the expression of inflammatory proteins. These results suggest that components of the bell pepper leaf extract possess anti-inflammatory activity. The study of the anti-inflammatory mechanism of bell pepper leaf extract has provided useful information on its potential for therapeutic application.
机译：水果和蔬菜已被认为是各种生物活性化合物的天然来源。辣椒，一种这样的自然来源，作为香料作物消费全世界。它们在传统医学中另外在传统医学中具有重要作用，因此通过激进清除抗氧化生物活性。然而，没有关于甜椒的生物活性（Capsicum Annum L. Var。Grossum）的报道，常用的食用蔬菜。本研究旨在评估水提取物从小鼠脾细胞叶片中水提取物的抗炎作用，探讨这种效果的潜在机制。通过在去离子水中的甜椒叶均化制备提取物。将灭菌的上清液加入到由康丹林A刺激的小鼠脾细胞培养物中。在72小时后，使用夹心酶联免疫吸附测定系统测量培养上清液中炎性细胞因子的水平，评估炎症蛋白的水平使用Western Blotting。甜椒叶提取物显着抑制炎症细胞因子产生，抑制细胞增殖而不产生细胞毒性，并抑制炎症蛋白的表达。这些结果表明甜椒叶提取物的组分具有抗炎活动。对甜椒叶提取物的抗炎机制的研究提供了有关其治疗应用潜力的有用信息。

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