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首页> 美国卫生研究院文献>Experimental and Therapeutic Medicine >Efficacy of fulguration combined with imiquimod cream on condyloma acuminatum and the effect on immune functions and serums levels of IL-2 and IL-10
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Efficacy of fulguration combined with imiquimod cream on condyloma acuminatum and the effect on immune functions and serums levels of IL-2 and IL-10

机译：肤敏联合咪喹莫特乳膏治疗尖锐湿疣及其对免疫功能和血清IL-2和IL-10水平的影响

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The objective of the present study was to investigate the clinical efficacy of high-frequency fulguration combined with 5% imiquimod cream for condyloma acuminatum (CA), and the effect on T cell immune function and serum levels of interleukin (IL)-2 and IL-10. We enrolled 112 patients with CA between January 2014 and January 2016. Patients were randomly divided into the control group (n=56) and observation group (n=56). The control group received high-frequency fulguration combined with intramuscular injection of Bacillus Calmette-Guérin polysaccharide nucleic acid, and the observation group received high-frequency fulguration combined with external application of 5% imiquimod cream. In both groups, the course of treatment lasted for 12 weeks, and the follow-up period was 6 months. Clinical efficacy was compared between the groups. The total effective rate in the observation group was higher than that in the control group (p<0.05), but no significant differences were identified in comparisons of effectiveness and recurrence rate between the two groups (p>0.05). After treatment, the levels of CD3+ and CD4+ cells, and CD4+/CD8+ ratio in both groups were increased compared with those before treatment (p<0.05), while no significant difference was identified in comparison of the levels of CD8+ cells in both groups before and after treatment (p>0.05); in both groups before and after treatment, there was no significant difference in the comparison of T cells (p>0.05). After treatment in both groups, the serum levels of IL-2 were increased, and the levels of IL-10 were decreased compared with those before treatment; the improvement in the observation group was superior to that in the control group (p<0.05). In conclusion, good efficacy can be achieved with the combined treatment of high-frequency fulguration and 5% imiquimod cream for CA, which is correlated with enhanced immune functions of T cells, and improvements in the serum levels of IL-2 and IL-10.
机译：本研究的目的是研究高频电灼联合5％咪喹莫特乳膏治疗尖锐湿疣（CA）的临床疗效，以及对T细胞免疫功能以及血清白介素（IL）-2和IL水平的影响-10。我们在2014年1月至2016年1月期间招募了112例CA患者。患者被随机分为对照组（n = 56）和观察组（n = 56）。对照组接受高频电灼联合肌内注射卡介苗芽孢杆菌多糖核酸，观察组联合高频电灼联合外用5％咪喹莫特乳膏。在两组中，治疗过程持续12周，随访期为6个月。比较两组之间的临床疗效。观察组的总有效率高于对照组（p <0.05），但在两组的有效性和复发率的比较中没有发现显着差异（p> 0.05）。治疗后，两者中CD3 + 和CD4 + 细胞的水平以及CD4 + / CD8 + 的比率与治疗前相比，各组均增加（p <0.05），而治疗前后两组CD8 + 细胞水平比较均无显着差异（p> 0.05）；两组治疗前后比较，T细胞比较差异均无统计学意义（P> 0.05）。两组治疗后血清IL-2水平较治疗前均升高，IL-10水平较治疗前降低。观察组的改善优于对照组（p <0.05）。综上所述，高频电灼和5％咪喹莫特乳膏联合治疗CA可取得良好疗效，这与T细胞免疫功能增强，血清IL-2和IL-10水平提高有关。

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